Studies on Synthesis of Hypotensive Compounds. I. : Synthesis of Methoxy and Ethoxycarbonyloxy Benzoates

In relation to the structure of reserpine, 4-(N, N-diethylamino)-butanol and 6-(N, N-diethylamino)-hexanol esters of benzoic acid having methoxy or ethoxycarbonyloxy groups were perpared as acid -addition salts, or quaternary ammonium salts. Hypotensive activity of these 13 new compounds were tested...

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Veröffentlicht in:	YAKUGAKU ZASSHI 1970/08/25, Vol.90(8), pp.1048-1051
1. Verfasser:	TOMIOKA, TATSUO
Format:	Artikel
Sprache:	jpn
Schlagworte:	Alcohols Animals Antihypertensive Agents - chemical synthesis Antihypertensive Agents - pharmacology Benzoates - chemical synthesis Benzoates - pharmacology Esters - chemical synthesis Ethylamines Mice
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description	In relation to the structure of reserpine, 4-(N, N-diethylamino)-butanol and 6-(N, N-diethylamino)-hexanol esters of benzoic acid having methoxy or ethoxycarbonyloxy groups were perpared as acid -addition salts, or quaternary ammonium salts. Hypotensive activity of these 13 new compounds were tested (Table I).
doi_str_mv	10.1248/yakushi1947.90.8_1048
format	Article
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I. : Synthesis of Methoxy and Ethoxycarbonyloxy Benzoates</title><title>YAKUGAKU ZASSHI</title><addtitle>YAKUGAKU ZASSHI</addtitle><description>In relation to the structure of reserpine, 4-(N, N-diethylamino)-butanol and 6-(N, N-diethylamino)-hexanol esters of benzoic acid having methoxy or ethoxycarbonyloxy groups were perpared as acid -addition salts, or quaternary ammonium salts. Hypotensive activity of these 13 new compounds were tested (Table I).</description><subject>Alcohols</subject><subject>Animals</subject><subject>Antihypertensive Agents - chemical synthesis</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Benzoates - chemical synthesis</subject><subject>Benzoates - pharmacology</subject><subject>Esters - chemical synthesis</subject><subject>Ethylamines</subject><subject>Mice</subject><issn>0031-6903</issn><issn>1347-5231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkT1PwzAQhi0EgqrwEyplYks4x47jsEFVaKUiBmC2nORKUlK7xA4i_HoCrSq44b7eRzfcS8iEQkRjLq96_da5qqYZT6MMIqkocHlERpTxNExiRo_JCIDRUGTAzsiFc3UOEA-RUHlKThMuBBUwItWT78oaXWBN8NQbX6Grh2EVzPut9Whc_YHB1G62tjOli4JFFFz_Bx_QV_azD7Qpg9lvW-g2t6Zvfra3aL6s9ujOyclKNw4v9nVMXu5mz9N5uHy8X0xvluGaSuHDGDO9koxjilQWItECNeZQUs2ykoFMGbJEyzSn8QqAM0hKLgsuQKdSxMjYmFzu7m5b-96h82pTuwKbRhu0nVOSi0ymkAzgZA92-QZLtW3rjW57tX_NoM93-tp5_YoHXbe-LhpUfyxQGSi5Sz8-HJCi0q1Cw74Bq6mDtg</recordid><startdate>197008</startdate><enddate>197008</enddate><creator>TOMIOKA, TATSUO</creator><general>The Pharmaceutical Society of Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197008</creationdate><title>Studies on Synthesis of Hypotensive Compounds. 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source	J-STAGE Free; MEDLINE; Alma/SFX Local Collection
subjects	Alcohols Animals Antihypertensive Agents - chemical synthesis Antihypertensive Agents - pharmacology Benzoates - chemical synthesis Benzoates - pharmacology Esters - chemical synthesis Ethylamines Mice
title	Studies on Synthesis of Hypotensive Compounds. I. : Synthesis of Methoxy and Ethoxycarbonyloxy Benzoates
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