Studies on Synthesis of Hypotensive Compounds. I. : Synthesis of Methoxy and Ethoxycarbonyloxy Benzoates

In relation to the structure of reserpine, 4-(N, N-diethylamino)-butanol and 6-(N, N-diethylamino)-hexanol esters of benzoic acid having methoxy or ethoxycarbonyloxy groups were perpared as acid -addition salts, or quaternary ammonium salts. Hypotensive activity of these 13 new compounds were tested (Table I).