Flow rate models in renal obstruction
Background In acute unilateral renal obstruction, calculated divided renal uptake following injection of tracer may be normal. Divided renal function as measured by uptake may be insensitive to fall in renal plasma flow (RPF) to the obstructed kidney. This study analyses afferent flow rate parameter...
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| description | Background
In acute unilateral renal obstruction, calculated divided renal uptake following injection of tracer may be normal. Divided renal function as measured by uptake may be insensitive to fall in renal plasma flow (RPF) to the obstructed kidney. This study analyses afferent flow rate parameters of optimised models of renogram time activity curves (TAC). Afferent flow rate parameters may have differing sensitivity to altered RPF from divided renal tracer uptake and may be more sensitive to changes in cortical function in renal obstruction.
Method
Twenty-four background-corrected renogram TACs using
99m
Tc-labelled mercapto-acetyl-triglycine (MAG3) with a unilateral obstructive pattern and six normal control renograms TACs were studied. Optimised computed models of each curve were constructed using specialised software (ModelMaker, Cherwell Scientific) and using the Marquardt Least Squares method. Following optimisation to the TAC of each target renogram, the afferent flow rate parameters were calculated.
Results
Following optimisation of models, afferent flow rate parameters, expressed as arbitrary units, (mean 0.15, SD 0.06) in acutely obstructed kidneys, were typically reduced in comparison with those of normal kidneys (mean 0.44, SD 0.04). (Paired
t
test;
P
|
| doi_str_mv | 10.1007/s00345-010-0569-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_846898204</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2244565911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c400t-744276478001c6f4f7908b0c209232592559652a520ca2310b0514f64c62b9c93</originalsourceid><addsrcrecordid>eNp1kE1Lw0AQhhdRbK3-AC8ShOIpOvu9e5RiVSh40fOy2W4kJU3qboL4792QakHwNId53pmXB6FLDLcYQN5FAMp4Dhhy4ELn6ghNMaM0V5KIYzQFSVjOtKITdBbjBgBLAfwUTQhwTCjDUzRf1u1nFmzns2279nXMqiYLvrF11haxC73rqrY5RyelraO_2M8Zels-vC6e8tXL4_PifpU7BtDlkjEiBZMqfXKiZKXUoApwBDShhGvCuRacWE7AWUIxFKkHKwVzghTaaTpDN-PdXWg_eh87s62i83VtG9_20SgmlFYEWCKv_5Cbtg-p9gBxhRkXIkF4hFxoYwy-NLtQbW34MhjMYNCMBk0yaAaDRqXM1f5wX2z9-jfxoywB8z1go7N1GWzjqnjgqGJK8KEhGbmYVs27D4eG_3__Bvikg58</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>845814566</pqid></control><display><type>article</type><title>Flow rate models in renal obstruction</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Coffey, J. P.</creator><creatorcontrib>Coffey, J. P.</creatorcontrib><description>Background
In acute unilateral renal obstruction, calculated divided renal uptake following injection of tracer may be normal. Divided renal function as measured by uptake may be insensitive to fall in renal plasma flow (RPF) to the obstructed kidney. This study analyses afferent flow rate parameters of optimised models of renogram time activity curves (TAC). Afferent flow rate parameters may have differing sensitivity to altered RPF from divided renal tracer uptake and may be more sensitive to changes in cortical function in renal obstruction.
Method
Twenty-four background-corrected renogram TACs using
99m
Tc-labelled mercapto-acetyl-triglycine (MAG3) with a unilateral obstructive pattern and six normal control renograms TACs were studied. Optimised computed models of each curve were constructed using specialised software (ModelMaker, Cherwell Scientific) and using the Marquardt Least Squares method. Following optimisation to the TAC of each target renogram, the afferent flow rate parameters were calculated.
Results
Following optimisation of models, afferent flow rate parameters, expressed as arbitrary units, (mean 0.15, SD 0.06) in acutely obstructed kidneys, were typically reduced in comparison with those of normal kidneys (mean 0.44, SD 0.04). (Paired
t
test;
P
< 0.005). By contrast, this reduction in afferent flow rate parameter was greater than the reduction in differential tracer uptake for the obstructed kidney (divided renal function of the obstructed group; mean 0.3, SD 0.14 compared with the control group; mean 0.45, SD 0.05 (
P
< 0.05).
Conclusion
Optimised modelling of TACs of obstructed renograms is feasible and may provide a more sensitive index of parenchymal dysfunction in early obstruction than comparing divided renal tracer uptake.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/s00345-010-0569-8</identifier><identifier>PMID: 20512341</identifier><identifier>CODEN: WJURDJ</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Case-Control Studies ; Child ; Child, Preschool ; Computer Simulation ; Humans ; Kidney - physiopathology ; Kidney Diseases - diagnostic imaging ; Kidney Diseases - physiopathology ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Models, Biological ; Nephrology ; Nephrology. Urinary tract diseases ; Oncology ; Original Article ; Radioisotope Renography ; Sensitivity and Specificity ; Time Factors ; Ureteral Obstruction - diagnostic imaging ; Ureteral Obstruction - physiopathology ; Urology ; Young Adult</subject><ispartof>World journal of urology, 2011-02, Vol.29 (1), p.109-114</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-744276478001c6f4f7908b0c209232592559652a520ca2310b0514f64c62b9c93</citedby><cites>FETCH-LOGICAL-c400t-744276478001c6f4f7908b0c209232592559652a520ca2310b0514f64c62b9c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00345-010-0569-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00345-010-0569-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23848654$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20512341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coffey, J. P.</creatorcontrib><title>Flow rate models in renal obstruction</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><addtitle>World J Urol</addtitle><description>Background
In acute unilateral renal obstruction, calculated divided renal uptake following injection of tracer may be normal. Divided renal function as measured by uptake may be insensitive to fall in renal plasma flow (RPF) to the obstructed kidney. This study analyses afferent flow rate parameters of optimised models of renogram time activity curves (TAC). Afferent flow rate parameters may have differing sensitivity to altered RPF from divided renal tracer uptake and may be more sensitive to changes in cortical function in renal obstruction.
Method
Twenty-four background-corrected renogram TACs using
99m
Tc-labelled mercapto-acetyl-triglycine (MAG3) with a unilateral obstructive pattern and six normal control renograms TACs were studied. Optimised computed models of each curve were constructed using specialised software (ModelMaker, Cherwell Scientific) and using the Marquardt Least Squares method. Following optimisation to the TAC of each target renogram, the afferent flow rate parameters were calculated.
Results
Following optimisation of models, afferent flow rate parameters, expressed as arbitrary units, (mean 0.15, SD 0.06) in acutely obstructed kidneys, were typically reduced in comparison with those of normal kidneys (mean 0.44, SD 0.04). (Paired
t
test;
P
< 0.005). By contrast, this reduction in afferent flow rate parameter was greater than the reduction in differential tracer uptake for the obstructed kidney (divided renal function of the obstructed group; mean 0.3, SD 0.14 compared with the control group; mean 0.45, SD 0.05 (
P
< 0.05).
Conclusion
Optimised modelling of TACs of obstructed renograms is feasible and may provide a more sensitive index of parenchymal dysfunction in early obstruction than comparing divided renal tracer uptake.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Computer Simulation</subject><subject>Humans</subject><subject>Kidney - physiopathology</subject><subject>Kidney Diseases - diagnostic imaging</subject><subject>Kidney Diseases - physiopathology</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Nephrology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Radioisotope Renography</subject><subject>Sensitivity and Specificity</subject><subject>Time Factors</subject><subject>Ureteral Obstruction - diagnostic imaging</subject><subject>Ureteral Obstruction - physiopathology</subject><subject>Urology</subject><subject>Young Adult</subject><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1Lw0AQhhdRbK3-AC8ShOIpOvu9e5RiVSh40fOy2W4kJU3qboL4792QakHwNId53pmXB6FLDLcYQN5FAMp4Dhhy4ELn6ghNMaM0V5KIYzQFSVjOtKITdBbjBgBLAfwUTQhwTCjDUzRf1u1nFmzns2279nXMqiYLvrF11haxC73rqrY5RyelraO_2M8Zels-vC6e8tXL4_PifpU7BtDlkjEiBZMqfXKiZKXUoApwBDShhGvCuRacWE7AWUIxFKkHKwVzghTaaTpDN-PdXWg_eh87s62i83VtG9_20SgmlFYEWCKv_5Cbtg-p9gBxhRkXIkF4hFxoYwy-NLtQbW34MhjMYNCMBk0yaAaDRqXM1f5wX2z9-jfxoywB8z1go7N1GWzjqnjgqGJK8KEhGbmYVs27D4eG_3__Bvikg58</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Coffey, J. P.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Flow rate models in renal obstruction</title><author>Coffey, J. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-744276478001c6f4f7908b0c209232592559652a520ca2310b0514f64c62b9c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Computer Simulation</topic><topic>Humans</topic><topic>Kidney - physiopathology</topic><topic>Kidney Diseases - diagnostic imaging</topic><topic>Kidney Diseases - physiopathology</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Nephrology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Radioisotope Renography</topic><topic>Sensitivity and Specificity</topic><topic>Time Factors</topic><topic>Ureteral Obstruction - diagnostic imaging</topic><topic>Ureteral Obstruction - physiopathology</topic><topic>Urology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coffey, J. P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coffey, J. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flow rate models in renal obstruction</atitle><jtitle>World journal of urology</jtitle><stitle>World J Urol</stitle><addtitle>World J Urol</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>29</volume><issue>1</issue><spage>109</spage><epage>114</epage><pages>109-114</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><coden>WJURDJ</coden><abstract>Background
In acute unilateral renal obstruction, calculated divided renal uptake following injection of tracer may be normal. Divided renal function as measured by uptake may be insensitive to fall in renal plasma flow (RPF) to the obstructed kidney. This study analyses afferent flow rate parameters of optimised models of renogram time activity curves (TAC). Afferent flow rate parameters may have differing sensitivity to altered RPF from divided renal tracer uptake and may be more sensitive to changes in cortical function in renal obstruction.
Method
Twenty-four background-corrected renogram TACs using
99m
Tc-labelled mercapto-acetyl-triglycine (MAG3) with a unilateral obstructive pattern and six normal control renograms TACs were studied. Optimised computed models of each curve were constructed using specialised software (ModelMaker, Cherwell Scientific) and using the Marquardt Least Squares method. Following optimisation to the TAC of each target renogram, the afferent flow rate parameters were calculated.
Results
Following optimisation of models, afferent flow rate parameters, expressed as arbitrary units, (mean 0.15, SD 0.06) in acutely obstructed kidneys, were typically reduced in comparison with those of normal kidneys (mean 0.44, SD 0.04). (Paired
t
test;
P
< 0.005). By contrast, this reduction in afferent flow rate parameter was greater than the reduction in differential tracer uptake for the obstructed kidney (divided renal function of the obstructed group; mean 0.3, SD 0.14 compared with the control group; mean 0.45, SD 0.05 (
P
< 0.05).
Conclusion
Optimised modelling of TACs of obstructed renograms is feasible and may provide a more sensitive index of parenchymal dysfunction in early obstruction than comparing divided renal tracer uptake.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20512341</pmid><doi>10.1007/s00345-010-0569-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Case-Control Studies Child Child, Preschool Computer Simulation Humans Kidney - physiopathology Kidney Diseases - diagnostic imaging Kidney Diseases - physiopathology Medical sciences Medicine Medicine & Public Health Middle Aged Models, Biological Nephrology Nephrology. Urinary tract diseases Oncology Original Article Radioisotope Renography Sensitivity and Specificity Time Factors Ureteral Obstruction - diagnostic imaging Ureteral Obstruction - physiopathology Urology Young Adult |
| title | Flow rate models in renal obstruction |
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