Flow rate models in renal obstruction

Background In acute unilateral renal obstruction, calculated divided renal uptake following injection of tracer may be normal. Divided renal function as measured by uptake may be insensitive to fall in renal plasma flow (RPF) to the obstructed kidney. This study analyses afferent flow rate parameters of optimised models of renogram time activity curves (TAC). Afferent flow rate parameters may have differing sensitivity to altered RPF from divided renal tracer uptake and may be more sensitive to changes in cortical function in renal obstruction. Method Twenty-four background-corrected renogram TACs using 99m Tc-labelled mercapto-acetyl-triglycine (MAG3) with a unilateral obstructive pattern and six normal control renograms TACs were studied. Optimised computed models of each curve were constructed using specialised software (ModelMaker, Cherwell Scientific) and using the Marquardt Least Squares method. Following optimisation to the TAC of each target renogram, the afferent flow rate parameters were calculated. Results Following optimisation of models, afferent flow rate parameters, expressed as arbitrary units, (mean 0.15, SD 0.06) in acutely obstructed kidneys, were typically reduced in comparison with those of normal kidneys (mean 0.44, SD 0.04). (Paired t test; P