The C-Alkyl-aminomethylation of 3-Pyridazinol 1-Oxide Derivatives. I

The Mannich reaction of 3-pyridazinol 1-oxide using morpholine, piperidine, or dimethylamine gave the corresponding 6-alkylaminomethyl-3-pyridazinol 1-oxides which were also synthesized from 3-methoxy-6-chloromethylpyridazine.

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1967/08/25, Vol.15(8), pp.1172-1177
Hauptverfasser: Okusa, Genzo, Kamiya, Shozo, Itai, Takanobu
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container_title Chemical & pharmaceutical bulletin
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creator Okusa, Genzo
Kamiya, Shozo
Itai, Takanobu
description The Mannich reaction of 3-pyridazinol 1-oxide using morpholine, piperidine, or dimethylamine gave the corresponding 6-alkylaminomethyl-3-pyridazinol 1-oxides which were also synthesized from 3-methoxy-6-chloromethylpyridazine.
doi_str_mv 10.1248/cpb.15.1172
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subjects Methylation
Pyridazines
title The C-Alkyl-aminomethylation of 3-Pyridazinol 1-Oxide Derivatives. I
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