Leukocyte Antigen-Antibody Reaction and Lysis of Paroxysmal Nocturnal Hemoglobinuria Erythrocytes

The interaction between leukocyte antigens and specific antibodies can cause lysis of the red cells of paroxysmal nocturnal hemoglobinuria (PNH) in vitro. It is suggested that the activation of complement ensuing from the antigen-antibody interaction is responsible for PNH cell lysis. The clinical i...

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Veröffentlicht in:	Blood 1970-09, Vol.36 (3), p.334-336
Hauptverfasser:	Sirchia, Girolamo, Ferrone, Soldano, Mercuriali, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Anti-Idiotypic Antigen-Antibody Reactions Bromelains Complement System Proteins Erythrocytes - immunology Hemoglobinuria, Paroxysmal - immunology Hemolysis Humans Immune Sera In Vitro Techniques Isoantibodies Leukemia, Lymphoid - blood Leukocytes - immunology
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Beschreibung
Zusammenfassung:	The interaction between leukocyte antigens and specific antibodies can cause lysis of the red cells of paroxysmal nocturnal hemoglobinuria (PNH) in vitro. It is suggested that the activation of complement ensuing from the antigen-antibody interaction is responsible for PNH cell lysis. The clinical implications of this finding are briefly outlined.
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood.V36.3.334.334