Acetylsalicylic Acid: No Chromosome Damage in Human Leukocytes
Acetylsalicylic acid was added to cultures of human leukocytes at several time periods over a wide range of concentrations (0.1 to 300.0 micrograms per milliliter). Leukocytes were also cultured from human volunteers during the ingestion of two 300-milligram tablets four times daily (2400 milligrams...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1970-07, Vol.169 (3941), p.198-201 |
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| container_issue | 3941 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 169 |
| creator | Mauer, Irving Weinstein, David Solomon, Harvey M. |
| description | Acetylsalicylic acid was added to cultures of human leukocytes at several time periods over a wide range of concentrations (0.1 to 300.0 micrograms per milliliter). Leukocytes were also cultured from human volunteers during the ingestion of two 300-milligram tablets four times daily (2400 milligrams per day) over a 1-month period. No significant increase in chromosome oberrations was detected in vitro or in vivo. |
| doi_str_mv | 10.1126/science.169.3941.198 |
| format | Article |
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No significant increase in chromosome oberrations was detected in vitro or in vivo.</description><subject>Aspirin - pharmacology</subject><subject>Blood plasma</subject><subject>Chromosome Aberrations - drug effects</subject><subject>Chromosomes</subject><subject>Culture Techniques</subject><subject>Cultured cells</subject><subject>Cytogenetics</subject><subject>Flood damage</subject><subject>Human genetics</subject><subject>Humans</subject><subject>Leukocytes</subject><subject>Leukocytes - cytology</subject><subject>Medical genetics</subject><subject>Mitosis</subject><subject>Radiation damage</subject><subject>Writing tablets</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS0EKqXwB0XKil2CHb9iFkhVeRSpgg2sLdeeQEpSlzhZ5O9x1QgWo1mcO1ejg9Cc4IyQXNwGW8HOQkaEyqhiJCOqOEFTghVPVY7pKZpiTEVaYMnP0UUIW4wjU3SCJpzlknI-RfcLC91QB1NXdoiTLGzl7pJXnyy_Wt_44BtIHkxjPiGpdsmqb8wuWUP_7e3QQbhEZ6WpA1yNe4Y-nh7fl6t0_fb8slysU0s57VJDBDNFSbEREgPQEmTpmDLcOSo2shDS4FxJspHGcWyUw_E7a3ObMxepoDN0c-zdt_6nh9DppgoW6trswPdBF0wwySmLQXYM2taH0EKp923VmHbQBOuDNj1q01GbPmjTUVs8ux77-00D7u9o9BT5_Mi3ofPtf6ekmOac_gLFf3Mv</recordid><startdate>19700710</startdate><enddate>19700710</enddate><creator>Mauer, Irving</creator><creator>Weinstein, David</creator><creator>Solomon, Harvey M.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19700710</creationdate><title>Acetylsalicylic Acid: No Chromosome Damage in Human Leukocytes</title><author>Mauer, Irving ; Weinstein, David ; Solomon, Harvey M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-a164a8f30a670ee3fe7fd49a5dd36b7867a02971b7ad50a9d0735cc2c24d78663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Aspirin - pharmacology</topic><topic>Blood plasma</topic><topic>Chromosome Aberrations - drug effects</topic><topic>Chromosomes</topic><topic>Culture Techniques</topic><topic>Cultured cells</topic><topic>Cytogenetics</topic><topic>Flood damage</topic><topic>Human genetics</topic><topic>Humans</topic><topic>Leukocytes</topic><topic>Leukocytes - cytology</topic><topic>Medical genetics</topic><topic>Mitosis</topic><topic>Radiation damage</topic><topic>Writing tablets</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mauer, Irving</creatorcontrib><creatorcontrib>Weinstein, David</creatorcontrib><creatorcontrib>Solomon, Harvey M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mauer, Irving</au><au>Weinstein, David</au><au>Solomon, Harvey M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acetylsalicylic Acid: No Chromosome Damage in Human Leukocytes</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1970-07-10</date><risdate>1970</risdate><volume>169</volume><issue>3941</issue><spage>198</spage><epage>201</epage><pages>198-201</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Acetylsalicylic acid was added to cultures of human leukocytes at several time periods over a wide range of concentrations (0.1 to 300.0 micrograms per milliliter). 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1970-07, Vol.169 (3941), p.198-201 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84647534 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Aspirin - pharmacology Blood plasma Chromosome Aberrations - drug effects Chromosomes Culture Techniques Cultured cells Cytogenetics Flood damage Human genetics Humans Leukocytes Leukocytes - cytology Medical genetics Mitosis Radiation damage Writing tablets |
| title | Acetylsalicylic Acid: No Chromosome Damage in Human Leukocytes |
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