Acetylsalicylic Acid: No Chromosome Damage in Human Leukocytes

Acetylsalicylic Acid: No Chromosome Damage in Human Leukocytes

Acetylsalicylic acid was added to cultures of human leukocytes at several time periods over a wide range of concentrations (0.1 to 300.0 micrograms per milliliter). Leukocytes were also cultured from human volunteers during the ingestion of two 300-milligram tablets four times daily (2400 milligrams...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1970-07, Vol.169 (3941), p.198-201
Hauptverfasser: Mauer, Irving, Weinstein, David, Solomon, Harvey M.
Format: Artikel
Sprache:eng
Schlagworte:
Aspirin - pharmacology
Blood plasma
Chromosome Aberrations - drug effects
Chromosomes
Culture Techniques
Cultured cells
Cytogenetics
Flood damage
Human genetics
Humans
Leukocytes
Leukocytes - cytology
Medical genetics
Mitosis
Radiation damage
Writing tablets
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Zusammenfassung:Acetylsalicylic acid was added to cultures of human leukocytes at several time periods over a wide range of concentrations (0.1 to 300.0 micrograms per milliliter). Leukocytes were also cultured from human volunteers during the ingestion of two 300-milligram tablets four times daily (2400 milligrams per day) over a 1-month period. No significant increase in chromosome oberrations was detected in vitro or in vivo.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.169.3941.198