Temporal Summation and Refractoriness in Hypothalamic Reward Neurons as Measured by Self-Stimulation Behavior
A neurophysiological technique of double-pulse stimulation has been applied to freely moving rats with chronic indwelling electrodes in the hypothalamic reward area. Self-stimulation thresholds, measured as a function of the interpulse interval, generated curves with time constants characteristic of...
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Veröffentlicht in: | Science (American Association for the Advancement of Science) 1970-08, Vol.169 (3947), p.782-785 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | A neurophysiological technique of double-pulse stimulation has been applied to freely moving rats with chronic indwelling electrodes in the hypothalamic reward area. Self-stimulation thresholds, measured as a function of the interpulse interval, generated curves with time constants characteristic of refractory periods and temporal synaptic summation. The results indicate a way of studying central neuronal processes for which the overt behavior of the animal is the dependent variable. |
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ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.169.3947.782 |