Changes in emotional behaviour after application of cholinesterase inhibitor in the septal and amygdala region

Local application of amitone (a cholinesterase inhibitor) in the septum pellucidum caused an increased aggressiveness and hyper-reactivity, and in some cases muricide in the rat. This increased reactivity was depressed by atropine. Amitone application to the amygdala can also lead to increased reactivity, and atropine had a depressant effect. Septal lesion performed previously did not change the increased reactivity to any great extent provided the cholinesterase inhibitor was applied locally to the baso-lateral part of the amygdala.