Ornithine Carbamoyltransferase Activity in Plasma of Mice with Malaria as an Index of Liver Damage
INCREASED concentrations of glutamic oxalacetic and glutamic pyruvic transaminases have been detected in the serum of mice infected with Plasmodium berghei , and they are thought to be connected with changes in the liver 1–4 . Transaminases, however, are found in tissues other than liver 5 and are p...
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| Veröffentlicht in: | Nature (London) 1967-09, Vol.215 (5109), p.1489-1491 |
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| creator | EINHEBER, ALBERT WREN, ROBERT E ROSEN, HYMAN MARTIN, LARRY K |
| description | INCREASED concentrations of glutamic oxalacetic and glutamic pyruvic transaminases have been detected in the serum of mice infected with
Plasmodium berghei
, and they are thought to be connected with changes in the liver
1–4
. Transaminases, however, are found in tissues other than liver
5
and are present in high concentrations in erythrocytes. Thus in clinical disorders associated with haemolysis, such as malaria, enzyme from lysed erythrocytes may contribute significantly to serum concentrations
2
. |
| doi_str_mv | 10.1038/2151489a0 |
| format | Article |
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Plasmodium berghei
, and they are thought to be connected with changes in the liver
1–4
. Transaminases, however, are found in tissues other than liver
5
and are present in high concentrations in erythrocytes. Thus in clinical disorders associated with haemolysis, such as malaria, enzyme from lysed erythrocytes may contribute significantly to serum concentrations
2
.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/2151489a0</identifier><identifier>PMID: 6059569</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Citrulline - blood ; Clinical Enzyme Tests ; Humanities and Social Sciences ; letter ; Liver Diseases, Parasitic - diagnosis ; Malaria - enzymology ; Mice ; multidisciplinary ; Ornithine Carbamoyltransferase - blood ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1967-09, Vol.215 (5109), p.1489-1491</ispartof><rights>Springer Nature Limited 1967</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-10ef0f427382d401e3bfc18da81c6a4467921df4ed1d11d02b8359975e0d3ee43</citedby><cites>FETCH-LOGICAL-c339t-10ef0f427382d401e3bfc18da81c6a4467921df4ed1d11d02b8359975e0d3ee43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6059569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EINHEBER, ALBERT</creatorcontrib><creatorcontrib>WREN, ROBERT E</creatorcontrib><creatorcontrib>ROSEN, HYMAN</creatorcontrib><creatorcontrib>MARTIN, LARRY K</creatorcontrib><title>Ornithine Carbamoyltransferase Activity in Plasma of Mice with Malaria as an Index of Liver Damage</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>INCREASED concentrations of glutamic oxalacetic and glutamic pyruvic transaminases have been detected in the serum of mice infected with
Plasmodium berghei
, and they are thought to be connected with changes in the liver
1–4
. Transaminases, however, are found in tissues other than liver
5
and are present in high concentrations in erythrocytes. Thus in clinical disorders associated with haemolysis, such as malaria, enzyme from lysed erythrocytes may contribute significantly to serum concentrations
2
.</description><subject>Animals</subject><subject>Citrulline - blood</subject><subject>Clinical Enzyme Tests</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Liver Diseases, Parasitic - diagnosis</subject><subject>Malaria - enzymology</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Ornithine Carbamoyltransferase - blood</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkD1PwzAURS0EglIY-AEIT0ggBezYSZyxKp9SKxhgjl7i52KUOGAnQP89qVqVhekN99wjvUvICWdXnAl1HfOES5UD2yEjLrM0kqnKdsmIsVhFTIn0gByG8M4YS3gm98l-ypI8SfMRKZ-8s92bdUin4Eto2mXdeXDBoIeAdFJ19st2S2odfa4hNEBbQ-e2Qvo99OgcavAWKAQKjj46jT8rYGa_0NMbaGCBR2TPQB3weHPH5PXu9mX6EM2e7h-nk1lUCZF3EWdomJFxJlSsJeMoSlNxpUHxKgUp0yyPuTYSNdecaxaXSiR5niXItECUYkzO194P3372GLqisaHCugaHbR8KJZM8zmQygBdrsPJtCB5N8eFtA35ZcFas9iy2ew7s6Ubalw3qLbkZcMgv13kYErdAX7y3vXfDn__Kztawg673uJX9Eb8YSIb3</recordid><startdate>19670930</startdate><enddate>19670930</enddate><creator>EINHEBER, ALBERT</creator><creator>WREN, ROBERT E</creator><creator>ROSEN, HYMAN</creator><creator>MARTIN, LARRY K</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19670930</creationdate><title>Ornithine Carbamoyltransferase Activity in Plasma of Mice with Malaria as an Index of Liver Damage</title><author>EINHEBER, ALBERT ; WREN, ROBERT E ; ROSEN, HYMAN ; MARTIN, LARRY K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-10ef0f427382d401e3bfc18da81c6a4467921df4ed1d11d02b8359975e0d3ee43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Animals</topic><topic>Citrulline - blood</topic><topic>Clinical Enzyme Tests</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Liver Diseases, Parasitic - diagnosis</topic><topic>Malaria - enzymology</topic><topic>Mice</topic><topic>multidisciplinary</topic><topic>Ornithine Carbamoyltransferase - blood</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EINHEBER, ALBERT</creatorcontrib><creatorcontrib>WREN, ROBERT E</creatorcontrib><creatorcontrib>ROSEN, HYMAN</creatorcontrib><creatorcontrib>MARTIN, LARRY K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EINHEBER, ALBERT</au><au>WREN, ROBERT E</au><au>ROSEN, HYMAN</au><au>MARTIN, LARRY K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ornithine Carbamoyltransferase Activity in Plasma of Mice with Malaria as an Index of Liver Damage</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1967-09-30</date><risdate>1967</risdate><volume>215</volume><issue>5109</issue><spage>1489</spage><epage>1491</epage><pages>1489-1491</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>INCREASED concentrations of glutamic oxalacetic and glutamic pyruvic transaminases have been detected in the serum of mice infected with
Plasmodium berghei
, and they are thought to be connected with changes in the liver
1–4
. Transaminases, however, are found in tissues other than liver
5
and are present in high concentrations in erythrocytes. Thus in clinical disorders associated with haemolysis, such as malaria, enzyme from lysed erythrocytes may contribute significantly to serum concentrations
2
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6059569</pmid><doi>10.1038/2151489a0</doi><tpages>3</tpages></addata></record> |
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| ispartof | Nature (London), 1967-09, Vol.215 (5109), p.1489-1491 |
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| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | Animals Citrulline - blood Clinical Enzyme Tests Humanities and Social Sciences letter Liver Diseases, Parasitic - diagnosis Malaria - enzymology Mice multidisciplinary Ornithine Carbamoyltransferase - blood Science Science (multidisciplinary) |
| title | Ornithine Carbamoyltransferase Activity in Plasma of Mice with Malaria as an Index of Liver Damage |
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