Immune Responses of Inbred Mice to Repeated Low Doses of Antigen: Relationship to Histocompatibility (H-2) Type

Immune Responses of Inbred Mice to Repeated Low Doses of Antigen: Relationship to Histocompatibility (H-2) Type

Immunization of inbred strains of mice with repeated minute doses (0.1 to 1.0 microgram) of hapten-protein conjugates demonstrated wide differences in the magnitude of their antibody responses, which were related to the histocompatibility (H-2) type of the strains. Immunization with a single high do...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1970-05, Vol.168 (3933), p.852-854
Hauptverfasser: Vaz, Nelson M., Levine, Bernard B.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antibodies
Antibody Formation
Antigens
Antigens - administration & dosage
Cellular immunity
Dinitrophenols
gamma-Globulins
Gels
Genetic loci
Haptens - administration & dosage
Haptens - pharmacology
Histocompatibility
Immunization
Immunoglobulin E
Inbred strains
Inbreeding
Mice
Mucoproteins
Penicillin G
Reagins
Ribonucleases
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Zusammenfassung:Immunization of inbred strains of mice with repeated minute doses (0.1 to 1.0 microgram) of hapten-protein conjugates demonstrated wide differences in the magnitude of their antibody responses, which were related to the histocompatibility (H-2) type of the strains. Immunization with a single high dose (100 micrograms) of antigen failed to demonstrate these differences.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.168.3933.852