Experimental Transmission of Feline Fibrosarcoma to Cats and Dogs

Experimental Transmission of Feline Fibrosarcoma to Cats and Dogs

An infectious C-type feline sarcoma virus (FSV), isolated from a naturally occurring fibrosarcoma of a domestic house cat, produces fibrosarcomas in kittens and puppies and induces cell transformation in feline embryo fibroblasts. Prenatal inoculation of cat and dog foetuses is particularly effectiv...

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Veröffentlicht in:Nature (London) 1970-05, Vol.226 (5248), p.807-809
Hauptverfasser: GARDNER, MURRAY B., RONGEY, ROBERT W., ARNSTEIN, PAUL, ESTES, JOHN D., SARMA, PADMAN, HUEBNER, ROBERT J., RICKARD, CHARLES G.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Animals, Newborn
Antigen-Antibody Reactions
Cat Diseases - microbiology
Cats
Cell Transformation, Neoplastic
Complement Fixation Tests
Dog Diseases - microbiology
Dogs
Fetus
Fibrosarcoma - immunology
Fibrosarcoma - microbiology
Fibrosarcoma - veterinary
Humanities and Social Sciences
multidisciplinary
Neoplasm Transplantation
Oncogenic Viruses - immunology
Oncogenic Viruses - pathogenicity
Science
Science (multidisciplinary)
Virus Cultivation
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Beschreibung
Zusammenfassung:An infectious C-type feline sarcoma virus (FSV), isolated from a naturally occurring fibrosarcoma of a domestic house cat, produces fibrosarcomas in kittens and puppies and induces cell transformation in feline embryo fibroblasts. Prenatal inoculation of cat and dog foetuses is particularly effective in tumour transmission. Postnatal dogs bearing FSV induced fibrosarcomas provide antisera suitable for detecting the feline C-type RNA tumour virus antigens in the complement fixation test.
ISSN:0028-0836
1476-4687
DOI:10.1038/226807a0