Pharmacokinetics and Antitumor Effects of the Drug Containing TNF-α in Nanoparticles
Antitumor activity of TNF-α incorporated in nanoparticles (VLP-TNF-α) and dynamics of its accumulation and elimination from the blood and tumor tissue were studied in ICR mice. The VLP-TNF-α preparation exhibited higher antitumor activity compared to free TNF-α, presumably due to longer circulation...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2010-09, Vol.149 (3), p.320-323 |
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| container_title | Bulletin of experimental biology and medicine |
| container_volume | 149 |
| creator | Gamaley, S. G Bateneva, A. V Sysoeva, G. M Danilenko, E. D Lebedev, L. R Masycheva, V. I |
| description | Antitumor activity of TNF-α incorporated in nanoparticles (VLP-TNF-α) and dynamics of its accumulation and elimination from the blood and tumor tissue were studied in ICR mice. The VLP-TNF-α preparation exhibited higher antitumor activity compared to free TNF-α, presumably due to longer circulation of the cytokine in the blood and its more intensive accumulation by tumor tissue. |
| doi_str_mv | 10.1007/s10517-010-0937-9 |
| format | Article |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Biomedical and Life Sciences Biomedicine Carcinoma, Ehrlich Tumor - drug therapy Cell Biology double-strand RNA Drug delivery systems Drugs Ehrlich carcinoma Injections, Intramuscular Internal Medicine Laboratory Medicine Mice Mice, Inbred ICR Nanoparticles Pathology pharmacokinetics Time Factors Tumor necrosis factor Tumor Necrosis Factor-alpha - administration & dosage Tumor Necrosis Factor-alpha - pharmacokinetics Tumor Necrosis Factor-alpha - pharmacology tumor necrosis factor-α Tumors Vehicles |
| title | Pharmacokinetics and Antitumor Effects of the Drug Containing TNF-α in Nanoparticles |
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