Pharmacokinetics and Antitumor Effects of the Drug Containing TNF-α in Nanoparticles

Antitumor activity of TNF-α incorporated in nanoparticles (VLP-TNF-α) and dynamics of its accumulation and elimination from the blood and tumor tissue were studied in ICR mice. The VLP-TNF-α preparation exhibited higher antitumor activity compared to free TNF-α, presumably due to longer circulation...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2010-09, Vol.149 (3), p.320-323
Hauptverfasser:	Gamaley, S. G, Bateneva, A. V, Sysoeva, G. M, Danilenko, E. D, Lebedev, L. R, Masycheva, V. I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Biomedical and Life Sciences Biomedicine Carcinoma, Ehrlich Tumor - drug therapy Cell Biology double-strand RNA Drug delivery systems Drugs Ehrlich carcinoma Injections, Intramuscular Internal Medicine Laboratory Medicine Mice Mice, Inbred ICR Nanoparticles Pathology pharmacokinetics Time Factors Tumor necrosis factor Tumor Necrosis Factor-alpha - administration & dosage Tumor Necrosis Factor-alpha - pharmacokinetics Tumor Necrosis Factor-alpha - pharmacology tumor necrosis factor-α Tumors Vehicles
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Zusammenfassung:	Antitumor activity of TNF-α incorporated in nanoparticles (VLP-TNF-α) and dynamics of its accumulation and elimination from the blood and tumor tissue were studied in ICR mice. The VLP-TNF-α preparation exhibited higher antitumor activity compared to free TNF-α, presumably due to longer circulation of the cytokine in the blood and its more intensive accumulation by tumor tissue.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-010-0937-9