Lymphocyte Activation: a Rapid Test to predict Allograft Rejection

Lymphocyte Activation: a Rapid Test to predict Allograft Rejection

THE early detection of allograft rejection, before organ function deteriorates, is an important objective of clinical research in transplantation immunology. Because lymphocytes play a central part in graft rejection 1,2 , attention was focused on these cells in the circulation of graft recipients....

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Veröffentlicht in:Nature (London) 1970-05, Vol.226 (5247), p.757-758
Hauptverfasser: HERSH, EVAN M, BUTLER, WILLIAM T, ROSSEN, ROGER D, MORGEN, ROBERT O
Format: Artikel
Sprache:eng
Schlagworte:
Histocompatibility Testing
Humanities and Social Sciences
Humans
letter
Lymphocytes - immunology
Lymphocytes - metabolism
Methods
multidisciplinary
Science
Science (multidisciplinary)
Thymidine - metabolism
Transplantation, Homologous
Tritium
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Zusammenfassung:THE early detection of allograft rejection, before organ function deteriorates, is an important objective of clinical research in transplantation immunology. Because lymphocytes play a central part in graft rejection 1,2 , attention was focused on these cells in the circulation of graft recipients. We observed that the numbers of circulating lymphocytes that incorporate 3 H-thymidine rise significantly during organ allograft rejection and may predict rejection crises by 24–48 h.
ISSN:0028-0836
1476-4687
DOI:10.1038/226757a0