Harderian Gland: Development and Influence of Early Hormonal Treatment on Porphyrin Content

The porphyrin content of the rat Harderian gland remains low until 12 days of age at which time both porphyrin content and concentration rapidly increase. Intraperitoneal administration of tetraiodothyronine (thyroxine) into newborn animals advances the appearance of porphyrin in the gland. Converse...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1970-05, Vol.168 (3934), p.996-998
Hauptverfasser:	Wetterberg, Lennart, Yuwiler, Arthur, Geller, Edward, Schapiro, Shawn
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Age Factors Animal glands Animals Animals, Newborn Body Weight Developmental biology Eyes Female Hospital administration Hydrocortisone - pharmacology Lacrimal Apparatus - drug effects Lacrimal Apparatus - growth & development Lacrimal Apparatus - metabolism Male Organ Size Pineal gland Porphyrins Porphyrins - analysis Porphyrins - metabolism Rats Thyroid gland Thyroxine - pharmacology Visual Cortex - physiology
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Beschreibung
Zusammenfassung:	The porphyrin content of the rat Harderian gland remains low until 12 days of age at which time both porphyrin content and concentration rapidly increase. Intraperitoneal administration of tetraiodothyronine (thyroxine) into newborn animals advances the appearance of porphyrin in the gland. Conversely, a single injection of cortisol acetate into newborns retards the appearance of porphyrin. The time of porphyrin appearance in the gland parallels the time for maturation of the evoked cortical response to visual stimulation in normal and hormone-treated animals.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.168.3934.996