INCIDENCE OF INFLUENZA VIRUS INFECTION IN EARLY INFANCY: A PROSPECTIVE STUDY IN SOUTH ASIA

INCIDENCE OF INFLUENZA VIRUS INFECTION IN EARLY INFANCY: A PROSPECTIVE STUDY IN SOUTH ASIA

We evaluated infant sera from an immunization trial in Bangladesh to assess influenza hemagglutination inhibition antibody titer increases in 131 unimmunized infants from birth to 6 months. We detected 31 serologically defined infections. Combined with 10 additional rapid test-proven influenza cases...

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Veröffentlicht in:The Pediatric infectious disease journal 2011-02, Vol.30 (2), p.170-173
Hauptverfasser: HENKLE, Emily, STEINHOFF, Mark C, OMER, Saad B, ROY, Eliza, ARIFEEN, Shams E, RAQIB, Rubhana, MCNEAL, Monica, BREIMAN, Robert F, MOSS, William J, ZAMAN, K
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies, Viral - blood
Asia - epidemiology
Biological and medical sciences
Female
Hemagglutination Inhibition Tests
Human viral diseases
Humans
Incidence
Infant
Infant, Newborn
Infectious diseases
Influenza, Human - epidemiology
Male
Medical sciences
Prospective Studies
Seroepidemiologic Studies
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
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Zusammenfassung:We evaluated infant sera from an immunization trial in Bangladesh to assess influenza hemagglutination inhibition antibody titer increases in 131 unimmunized infants from birth to 6 months. We detected 31 serologically defined infections. Combined with 10 additional rapid test-proven influenza cases, the minimal estimated incidence was 31 of 100 infants (95% CI: 24-41). These data suggest a high burden of influenza in young infants in tropical South Asia.
ISSN:0891-3668
1532-0987
DOI:10.1097/INF.0b013e3181f63c39