Cardiac Impairment in Adrenal Insufficiency in the Cat: Reduced Adenosinetriphosphatase Activity of Myocardial Contractile Proteins
Cardiac contractile protein ATPase activity was studied in cats 10 days after adrenalectomy at a time when the mean arterial blood pressure was 27% lower than that of control cats. The Ca-dependent, azide-insensitive ATPase activity of myofibrils isolated from the ventricles of adrenalectomized cats...
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| Veröffentlicht in: | Circulation research 1970-04, Vol.26 (4), p.419-428 |
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| container_title | Circulation research |
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| creator | ROVETTO, MICHAEL J MURPHY, RICHARD A LEFER, ALLAN M |
| description | Cardiac contractile protein ATPase activity was studied in cats 10 days after adrenalectomy at a time when the mean arterial blood pressure was 27% lower than that of control cats. The Ca-dependent, azide-insensitive ATPase activity of myofibrils isolated from the ventricles of adrenalectomized cats was 63% of the activity of control preparations (P |
| doi_str_mv | 10.1161/01.RES.26.4.419 |
| format | Article |
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The Ca-dependent, azide-insensitive ATPase activity of myofibrils isolated from the ventricles of adrenalectomized cats was 63% of the activity of control preparations (P <0.025). Similarly, the specific activities of cardiac actomyosin (myosin B) and myosin from adrenalectomized cats had decreased to 54 and 75% of control values, respectively (P <0.005). The percent reductions in ATPase activities in the three protein preparations from adrenalectomized animals were not significantly different, suggesting that the depression was associated with myosin per se. The reduction in the myosin ATPase activity in adrenal insufficiency was prevented by dexamethasone treatment adequate to prevent the decline in mean arterial blood pressure of the adrenalectomized cats. The reduction in cardiac performance in frank adrenal insufficiency may reflect a decrease in the rate of conversion of chemical to mechanical energy by the myocardial contractile proteins.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.RES.26.4.419</identifier><identifier>PMID: 4244919</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Adenosine Triphosphatases - metabolism ; Adrenal Insufficiency - enzymology ; Adrenalectomy ; Animals ; Blood Pressure ; Body Weight ; Calcium - metabolism ; Cats ; Female ; Heart - anatomy & histology ; Heart - physiopathology ; Male ; Muscle Proteins - isolation & purification ; Muscle Proteins - metabolism ; Myocardium - enzymology ; Myofibrils - enzymology ; Organ Size</subject><ispartof>Circulation research, 1970-04, Vol.26 (4), p.419-428</ispartof><rights>1970 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4244919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ROVETTO, MICHAEL J</creatorcontrib><creatorcontrib>MURPHY, RICHARD A</creatorcontrib><creatorcontrib>LEFER, ALLAN M</creatorcontrib><title>Cardiac Impairment in Adrenal Insufficiency in the Cat: Reduced Adenosinetriphosphatase Activity of Myocardial Contractile Proteins</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>Cardiac contractile protein ATPase activity was studied in cats 10 days after adrenalectomy at a time when the mean arterial blood pressure was 27% lower than that of control cats. The Ca-dependent, azide-insensitive ATPase activity of myofibrils isolated from the ventricles of adrenalectomized cats was 63% of the activity of control preparations (P <0.025). Similarly, the specific activities of cardiac actomyosin (myosin B) and myosin from adrenalectomized cats had decreased to 54 and 75% of control values, respectively (P <0.005). The percent reductions in ATPase activities in the three protein preparations from adrenalectomized animals were not significantly different, suggesting that the depression was associated with myosin per se. The reduction in the myosin ATPase activity in adrenal insufficiency was prevented by dexamethasone treatment adequate to prevent the decline in mean arterial blood pressure of the adrenalectomized cats. The reduction in cardiac performance in frank adrenal insufficiency may reflect a decrease in the rate of conversion of chemical to mechanical energy by the myocardial contractile proteins.</description><subject>Adenosine Triphosphatases - metabolism</subject><subject>Adrenal Insufficiency - enzymology</subject><subject>Adrenalectomy</subject><subject>Animals</subject><subject>Blood Pressure</subject><subject>Body Weight</subject><subject>Calcium - metabolism</subject><subject>Cats</subject><subject>Female</subject><subject>Heart - anatomy & histology</subject><subject>Heart - physiopathology</subject><subject>Male</subject><subject>Muscle Proteins - isolation & purification</subject><subject>Muscle Proteins - metabolism</subject><subject>Myocardium - enzymology</subject><subject>Myofibrils - enzymology</subject><subject>Organ Size</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kUGP1DAMhSMEWmYXzpyQcuLWrp2m7ZTbaLSwIy0CLXCO0tRVA21akpTVnPnjZJgRJ8t-n235mbE3CDlihbeA-ePd11xUucwlNs_YBkshM1nW-JxtAKDJ6qKAl-w6hB8AKAvRXLErKaRssNmwP3vtO6sNP0yLtn4iF7l1fNd5cnrkBxfWvrfGkjPHkxAH4nsd3_NH6lZDXSLJzcE6it4uwxyWQUcdiO9MtL9tPPK555-Os_m3ZuT72UWvkzYS_-LnSNaFV-xFr8dAry_xhn3_cPdtf589fP542O8eMlOIGjNRFoBb6Eluu5IqMAawLTVSjXVfG200dFBr01LbVtBhKbuyLhuZ8F6AEMUNe3eeu_j510ohqskGQ-OoHc1rUFtZFgmUCbw9g8bPIXjq1eLtpP1RIaiT7QpQJduVqJRUyfbU8fYyem0n6v7zF5-TLs_60zxG8uHnuD6RVwPpMQ4qvQnSbSLDpgaQKctOJSz-AuCRj0U</recordid><startdate>197004</startdate><enddate>197004</enddate><creator>ROVETTO, MICHAEL J</creator><creator>MURPHY, RICHARD A</creator><creator>LEFER, ALLAN M</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197004</creationdate><title>Cardiac Impairment in Adrenal Insufficiency in the Cat: Reduced Adenosinetriphosphatase Activity of Myocardial Contractile Proteins</title><author>ROVETTO, MICHAEL J ; MURPHY, RICHARD A ; LEFER, ALLAN M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3271-2530180fe48d5e60cc01b5a1e717f7caca0d07acbebb60d154d5759448df20223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Adenosine Triphosphatases - metabolism</topic><topic>Adrenal Insufficiency - enzymology</topic><topic>Adrenalectomy</topic><topic>Animals</topic><topic>Blood Pressure</topic><topic>Body Weight</topic><topic>Calcium - metabolism</topic><topic>Cats</topic><topic>Female</topic><topic>Heart - anatomy & histology</topic><topic>Heart - physiopathology</topic><topic>Male</topic><topic>Muscle Proteins - isolation & purification</topic><topic>Muscle Proteins - metabolism</topic><topic>Myocardium - enzymology</topic><topic>Myofibrils - enzymology</topic><topic>Organ Size</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROVETTO, MICHAEL J</creatorcontrib><creatorcontrib>MURPHY, RICHARD A</creatorcontrib><creatorcontrib>LEFER, ALLAN M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROVETTO, MICHAEL J</au><au>MURPHY, RICHARD A</au><au>LEFER, ALLAN M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac Impairment in Adrenal Insufficiency in the Cat: Reduced Adenosinetriphosphatase Activity of Myocardial Contractile Proteins</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1970-04</date><risdate>1970</risdate><volume>26</volume><issue>4</issue><spage>419</spage><epage>428</epage><pages>419-428</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>Cardiac contractile protein ATPase activity was studied in cats 10 days after adrenalectomy at a time when the mean arterial blood pressure was 27% lower than that of control cats. The Ca-dependent, azide-insensitive ATPase activity of myofibrils isolated from the ventricles of adrenalectomized cats was 63% of the activity of control preparations (P <0.025). Similarly, the specific activities of cardiac actomyosin (myosin B) and myosin from adrenalectomized cats had decreased to 54 and 75% of control values, respectively (P <0.005). The percent reductions in ATPase activities in the three protein preparations from adrenalectomized animals were not significantly different, suggesting that the depression was associated with myosin per se. The reduction in the myosin ATPase activity in adrenal insufficiency was prevented by dexamethasone treatment adequate to prevent the decline in mean arterial blood pressure of the adrenalectomized cats. The reduction in cardiac performance in frank adrenal insufficiency may reflect a decrease in the rate of conversion of chemical to mechanical energy by the myocardial contractile proteins.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>4244919</pmid><doi>10.1161/01.RES.26.4.419</doi><tpages>10</tpages></addata></record> |
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| ispartof | Circulation research, 1970-04, Vol.26 (4), p.419-428 |
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| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenosine Triphosphatases - metabolism Adrenal Insufficiency - enzymology Adrenalectomy Animals Blood Pressure Body Weight Calcium - metabolism Cats Female Heart - anatomy & histology Heart - physiopathology Male Muscle Proteins - isolation & purification Muscle Proteins - metabolism Myocardium - enzymology Myofibrils - enzymology Organ Size |
| title | Cardiac Impairment in Adrenal Insufficiency in the Cat: Reduced Adenosinetriphosphatase Activity of Myocardial Contractile Proteins |
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