Cardiac Impairment in Adrenal Insufficiency in the Cat: Reduced Adenosinetriphosphatase Activity of Myocardial Contractile Proteins

Cardiac contractile protein ATPase activity was studied in cats 10 days after adrenalectomy at a time when the mean arterial blood pressure was 27% lower than that of control cats. The Ca-dependent, azide-insensitive ATPase activity of myofibrils isolated from the ventricles of adrenalectomized cats...

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Veröffentlicht in:	Circulation research 1970-04, Vol.26 (4), p.419-428
Hauptverfasser:	ROVETTO, MICHAEL J, MURPHY, RICHARD A, LEFER, ALLAN M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Adrenal Insufficiency - enzymology Adrenalectomy Animals Blood Pressure Body Weight Calcium - metabolism Cats Female Heart - anatomy & histology Heart - physiopathology Male Muscle Proteins - isolation & purification Muscle Proteins - metabolism Myocardium - enzymology Myofibrils - enzymology Organ Size
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Zusammenfassung:	Cardiac contractile protein ATPase activity was studied in cats 10 days after adrenalectomy at a time when the mean arterial blood pressure was 27% lower than that of control cats. The Ca-dependent, azide-insensitive ATPase activity of myofibrils isolated from the ventricles of adrenalectomized cats was 63% of the activity of control preparations (P
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.RES.26.4.419