Biosynthesis of C-18-oxygenated corticosteroids by rabbit adrenals in vitro
Progesterone-4-C 14 and 11-dehydrocorticosterone-4-C 14 were incubated with rabbit adrenal tissue. Based on column chromatography and thin-layer techniques the biogenesis of 18-oxygenated corticosteroids was investigated. From progesterone-4-C 14 as substrate 18-hydroxy-corticosterone, aldosterone,...
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| Veröffentlicht in: | Steroids 1967-02, Vol.9 (2), p.177-191 |
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| container_title | Steroids |
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| creator | Fazekas, Arpad G. Kokai, Karoly |
| description | Progesterone-4-C
14 and 11-dehydrocorticosterone-4-C
14 were incubated with rabbit adrenal tissue. Based on column chromatography and thin-layer techniques the biogenesis of 18-oxygenated corticosteroids was investigated. From progesterone-4-C
14 as substrate 18-hydroxy-corticosterone, aldosterone, 18-hydroxy-11-dehydrocorticosterone and 11-dehydroaldosterone, from 11-dehydrocorticosterone-4-C
14 as substrate 18-hydroxy-11-dehydrocorticosterone and aldosterone were isolated. The significance of these transformations is discussed. |
| doi_str_mv | 10.1016/0039-128X(67)90040-2 |
| format | Article |
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14 and 11-dehydrocorticosterone-4-C
14 were incubated with rabbit adrenal tissue. Based on column chromatography and thin-layer techniques the biogenesis of 18-oxygenated corticosteroids was investigated. From progesterone-4-C
14 as substrate 18-hydroxy-corticosterone, aldosterone, 18-hydroxy-11-dehydrocorticosterone and 11-dehydroaldosterone, from 11-dehydrocorticosterone-4-C
14 as substrate 18-hydroxy-11-dehydrocorticosterone and aldosterone were isolated. The significance of these transformations is discussed.</description><identifier>ISSN: 0039-128X</identifier><identifier>EISSN: 1878-5867</identifier><identifier>DOI: 10.1016/0039-128X(67)90040-2</identifier><identifier>PMID: 6032310</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>11-β ; 20-dione ; 20-dione 11-dehydrocorticosterone/A ; 20-dione Deoxycorticosterone ; 20-trione Corticosterone/B ; 21-dihydroxy-4-pregnene-3 ; 21-hydroxy-4-pregnene-3 ; 4-pregnene-3 ; Adrenal Glands - metabolism ; Aldosterone - biosynthesis ; Animals ; Carbon Isotopes ; Chromatography, Thin Layer ; Corticosterone - biosynthesis ; Corticosterone - metabolism ; In Vitro Techniques ; Progesterone ; Progesterone - metabolism ; Rabbits</subject><ispartof>Steroids, 1967-02, Vol.9 (2), p.177-191</ispartof><rights>1967</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-dbfc28063f62bc090d81a04bcce67b23c4bb4e769fc1936a0c4b9038fa673bef3</citedby><cites>FETCH-LOGICAL-c357t-dbfc28063f62bc090d81a04bcce67b23c4bb4e769fc1936a0c4b9038fa673bef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0039128X67900402$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6032310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fazekas, Arpad G.</creatorcontrib><creatorcontrib>Kokai, Karoly</creatorcontrib><title>Biosynthesis of C-18-oxygenated corticosteroids by rabbit adrenals in vitro</title><title>Steroids</title><addtitle>Steroids</addtitle><description>Progesterone-4-C
14 and 11-dehydrocorticosterone-4-C
14 were incubated with rabbit adrenal tissue. Based on column chromatography and thin-layer techniques the biogenesis of 18-oxygenated corticosteroids was investigated. From progesterone-4-C
14 as substrate 18-hydroxy-corticosterone, aldosterone, 18-hydroxy-11-dehydrocorticosterone and 11-dehydroaldosterone, from 11-dehydrocorticosterone-4-C
14 as substrate 18-hydroxy-11-dehydrocorticosterone and aldosterone were isolated. The significance of these transformations is discussed.</description><subject>11-β</subject><subject>20-dione</subject><subject>20-dione 11-dehydrocorticosterone/A</subject><subject>20-dione Deoxycorticosterone</subject><subject>20-trione Corticosterone/B</subject><subject>21-dihydroxy-4-pregnene-3</subject><subject>21-hydroxy-4-pregnene-3</subject><subject>4-pregnene-3</subject><subject>Adrenal Glands - metabolism</subject><subject>Aldosterone - biosynthesis</subject><subject>Animals</subject><subject>Carbon Isotopes</subject><subject>Chromatography, Thin Layer</subject><subject>Corticosterone - biosynthesis</subject><subject>Corticosterone - metabolism</subject><subject>In Vitro Techniques</subject><subject>Progesterone</subject><subject>Progesterone - metabolism</subject><subject>Rabbits</subject><issn>0039-128X</issn><issn>1878-5867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PwzAMhiMEGmPwD0DqCcGh4DRdml6QYOJLTOICEreoSVwI2hpIson-ezI27cjJsv36tf0QckzhggLllwCszmkh3s54dV4DlJAXO2RIRSXyseDVLhluJfvkIIRPAOCsLgZkwIEVjMKQPN1YF_oufmCwIXNtNsmpyN1P_45dE9Fk2vlotQsRvbMmZKrPfKOUjVljfNLMQma7bGmjd4dkr005Hm3iiLze3b5MHvLp8_3j5HqaazauYm5UqwuRLml5oTTUYARtoFRaI69UwXSpVIkVr1tNa8YbSIUamGgbXjGFLRuR07Xvl3ffCwxRzm3QOJs1HbpFkKIc0zL5JmG5FmrvQvDYyi9v543vJQW5YihXgOQKkOSV_GMoizR2svFfqDma7dAGWupfrfuYnlxa9DJoi51GYz3qKI2z_y_4BSV3gUI</recordid><startdate>196702</startdate><enddate>196702</enddate><creator>Fazekas, Arpad G.</creator><creator>Kokai, Karoly</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196702</creationdate><title>Biosynthesis of C-18-oxygenated corticosteroids by rabbit adrenals in vitro</title><author>Fazekas, Arpad G. ; Kokai, Karoly</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-dbfc28063f62bc090d81a04bcce67b23c4bb4e769fc1936a0c4b9038fa673bef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>11-β</topic><topic>20-dione</topic><topic>20-dione 11-dehydrocorticosterone/A</topic><topic>20-dione Deoxycorticosterone</topic><topic>20-trione Corticosterone/B</topic><topic>21-dihydroxy-4-pregnene-3</topic><topic>21-hydroxy-4-pregnene-3</topic><topic>4-pregnene-3</topic><topic>Adrenal Glands - metabolism</topic><topic>Aldosterone - biosynthesis</topic><topic>Animals</topic><topic>Carbon Isotopes</topic><topic>Chromatography, Thin Layer</topic><topic>Corticosterone - biosynthesis</topic><topic>Corticosterone - metabolism</topic><topic>In Vitro Techniques</topic><topic>Progesterone</topic><topic>Progesterone - metabolism</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fazekas, Arpad G.</creatorcontrib><creatorcontrib>Kokai, Karoly</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Steroids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fazekas, Arpad G.</au><au>Kokai, Karoly</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biosynthesis of C-18-oxygenated corticosteroids by rabbit adrenals in vitro</atitle><jtitle>Steroids</jtitle><addtitle>Steroids</addtitle><date>1967-02</date><risdate>1967</risdate><volume>9</volume><issue>2</issue><spage>177</spage><epage>191</epage><pages>177-191</pages><issn>0039-128X</issn><eissn>1878-5867</eissn><abstract>Progesterone-4-C
14 and 11-dehydrocorticosterone-4-C
14 were incubated with rabbit adrenal tissue. Based on column chromatography and thin-layer techniques the biogenesis of 18-oxygenated corticosteroids was investigated. From progesterone-4-C
14 as substrate 18-hydroxy-corticosterone, aldosterone, 18-hydroxy-11-dehydrocorticosterone and 11-dehydroaldosterone, from 11-dehydrocorticosterone-4-C
14 as substrate 18-hydroxy-11-dehydrocorticosterone and aldosterone were isolated. The significance of these transformations is discussed.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6032310</pmid><doi>10.1016/0039-128X(67)90040-2</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-128X |
| ispartof | Steroids, 1967-02, Vol.9 (2), p.177-191 |
| issn | 0039-128X 1878-5867 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84514090 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 11-β 20-dione 20-dione 11-dehydrocorticosterone/A 20-dione Deoxycorticosterone 20-trione Corticosterone/B 21-dihydroxy-4-pregnene-3 21-hydroxy-4-pregnene-3 4-pregnene-3 Adrenal Glands - metabolism Aldosterone - biosynthesis Animals Carbon Isotopes Chromatography, Thin Layer Corticosterone - biosynthesis Corticosterone - metabolism In Vitro Techniques Progesterone Progesterone - metabolism Rabbits |
| title | Biosynthesis of C-18-oxygenated corticosteroids by rabbit adrenals in vitro |
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