Biosynthesis of C-18-oxygenated corticosteroids by rabbit adrenals in vitro

Progesterone-4-C 14 and 11-dehydrocorticosterone-4-C 14 were incubated with rabbit adrenal tissue. Based on column chromatography and thin-layer techniques the biogenesis of 18-oxygenated corticosteroids was investigated. From progesterone-4-C 14 as substrate 18-hydroxy-corticosterone, aldosterone,...

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Veröffentlicht in:	Steroids 1967-02, Vol.9 (2), p.177-191
Hauptverfasser:	Fazekas, Arpad G., Kokai, Karoly
Format:	Artikel
Sprache:	eng
Schlagworte:	11-β 20-dione 20-dione 11-dehydrocorticosterone/A 20-dione Deoxycorticosterone 20-trione Corticosterone/B 21-dihydroxy-4-pregnene-3 21-hydroxy-4-pregnene-3 4-pregnene-3 Adrenal Glands - metabolism Aldosterone - biosynthesis Animals Carbon Isotopes Chromatography, Thin Layer Corticosterone - biosynthesis Corticosterone - metabolism In Vitro Techniques Progesterone Progesterone - metabolism Rabbits
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Zusammenfassung:	Progesterone-4-C 14 and 11-dehydrocorticosterone-4-C 14 were incubated with rabbit adrenal tissue. Based on column chromatography and thin-layer techniques the biogenesis of 18-oxygenated corticosteroids was investigated. From progesterone-4-C 14 as substrate 18-hydroxy-corticosterone, aldosterone, 18-hydroxy-11-dehydrocorticosterone and 11-dehydroaldosterone, from 11-dehydrocorticosterone-4-C 14 as substrate 18-hydroxy-11-dehydrocorticosterone and aldosterone were isolated. The significance of these transformations is discussed.
ISSN:	0039-128X 1878-5867
DOI:	10.1016/0039-128X(67)90040-2