Effect of Route of Administration of Antilymphocytic Globulin on Skin Allograft Survival in Rats

ADMINISTRATION of antilymphocytic serum (ALS) or globulin (ALG) by subcutaneous 1 , intramuscular 2 , intraperitoneal 3 or intravenous 4 injection has been shown to prolong survival of allografts in various experimental systems. No data seem to be available, however, concerning the relative effect o...

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Veröffentlicht in:	Nature (London) 1970-03, Vol.225 (5238), p.1140-1141
Hauptverfasser:	DALTON, R. G, TOURAINE, J. L, ANDERSON, N. F, WOODRUFF, M. F. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antilymphocyte Serum - pharmacology Horses Humanities and Social Sciences Immunosuppressive Agents - pharmacology letter Male multidisciplinary Rats Science Science (multidisciplinary) Skin Transplantation Thoracic Duct - cytology Time Factors Transplantation Immunology - drug effects Transplantation, Homologous
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Beschreibung
Zusammenfassung:	ADMINISTRATION of antilymphocytic serum (ALS) or globulin (ALG) by subcutaneous 1 , intramuscular 2 , intraperitoneal 3 or intravenous 4 injection has been shown to prolong survival of allografts in various experimental systems. No data seem to be available, however, concerning the relative effect of administering the same dose of ALG by different routes on a particular graft in one species. We have compared the effect of daily intramuscular, intraperitoneal and intravenous injection, and continuous intravenous infusion, of ALG on skin allograft survival in rats.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/2251140a0