Gene Activation without Histone Acetylation in Drosophila melanogaster

Gene Activation without Histone Acetylation in Drosophila melanogaster

Chromosomal puffing, generally believed to represent gene activation in Drosophila, was induced in the presence of radioactively labeled acetate. There is no preferential uptake of these labeled molecules in regions of gene activation. It is concluded that the acetylation of histones does not play a...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1967-09, Vol.157 (3792), p.1070-1072
1. Verfasser: Ellgaard, Erik G.
Format: Artikel
Sprache:eng
Schlagworte:
Acetates
Acetates - metabolism
Acetylation
Animals
Autoradiography
Chromosomes
Drosophila
Drosophila - metabolism
Gene activation
Gene expression regulation
Genes
Histones
Histones - metabolism
RNA
RNA - biosynthesis
Salivary glands
Salivary Glands - cytology
Sodium
Tritium
Uridine - metabolism
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Beschreibung
Zusammenfassung:Chromosomal puffing, generally believed to represent gene activation in Drosophila, was induced in the presence of radioactively labeled acetate. There is no preferential uptake of these labeled molecules in regions of gene activation. It is concluded that the acetylation of histones does not play a general role in the regulation of RNA synthesis in Drosophila melanogaster.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.157.3792.1070