Flexible Nonisothermal Stability Studies

A method is described which allows ad libitum temperature adjustment during the course of a nonisothermal kinetic study. The data obtained are compared to theoretical degradation patterns to obtain from a single experiment activation energy, reaction rates, and stability predictions at any desired t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1970-03, Vol.59 (3), p.333-337
Hauptverfasser:	Maulding, H.V., Zoglio, M.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates Chemical Phenomena Chemistry Drug Stability Ethyl acetate hydrolysis-nonisothermal stability methodology Kinetic equations-flexible nonisothermal stability studies Kinetics Light Mathematics Methods nonisothermal Polarimetry-analysis Rotation Stability studies-flexible Stability studies—flexible, nonisothermal Sucrose Sucrose inversion-nonisothermal stability methodology Temperature Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A method is described which allows ad libitum temperature adjustment during the course of a nonisothermal kinetic study. The data obtained are compared to theoretical degradation patterns to obtain from a single experiment activation energy, reaction rates, and stability predictions at any desired temperature. The inversion of sucrose and the hydrolysis of ethyl acetate are studied to demonstrate the validity of the theory and the advantages of the method.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600590312