Immunologic studies in Burkitt's lymphoma

An evaluation of the immune status in patients with Burkitt's lymphoma was performed. Cellular immune responses were normal in both untreated patients and in patients in remission. An impairment of primary antibody response and low IgM levels were noted in untreated patients with Burkitt's...

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Veröffentlicht in:	Cancer 1970-03, Vol.25 (3), p.734-739
Hauptverfasser:	Ziegler, John L., Cohen, Martin H., Morrow, Richard H., Kyalwazi, Sebastian K., Carbone, Paul P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antibody Formation Burkitt Lymphoma - immunology Child Child, Preschool Female Hemagglutination Tests Humans Hypersensitivity, Delayed Immunodiffusion Immunoglobulin G - analysis Immunoglobulin M - analysis Immunologic Deficiency Syndromes - complications Lymphocyte Activation Lymphocytes - immunology Male Nitrobenzenes Skin Tests
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Zusammenfassung:	An evaluation of the immune status in patients with Burkitt's lymphoma was performed. Cellular immune responses were normal in both untreated patients and in patients in remission. An impairment of primary antibody response and low IgM levels were noted in untreated patients with Burkitt's lymphoma but not in patients in remission. A defect in humoral immunity associated with the presence of acive Burkitt's lymphoma is postulated; this defect is possibly related to IgM metabolism.
ISSN:	0008-543X 1097-0142
DOI:	10.1002/1097-0142(197003)25:3<734::AID-CNCR2820250335>3.0.CO;2-1