IDENTITY OF THE HÆMOPOIETIC STEM CELL

IDENTITY OF THE HÆMOPOIETIC STEM CELL

The main evidence for the hypothesis that the transitional cell in the lymphoid bone-marrow compartment is the hæmopoietic stem cell is as follows: quantitative changes in lymphoid cells in a variety of levels of erythropoietic activity point to the stem cell being within this group; the lack of any...

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Veröffentlicht in:The Lancet (British edition) 1967-01, Vol.290 (7515), p.547-548
Hauptverfasser: Moffatt, D.J., Rosse, C., Yoffey, J.M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Autoradiography
Basophils - physiology
Bone Marrow - drug effects
Bone Marrow - physiology
Bone Marrow Cells
Cell Division
Cell Nucleus - physiology
DNA - biosynthesis
Erythropoiesis - physiology
Guinea Pigs
Hematopoietic System - physiology
Thymidine - pharmacology
Tritium
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Beschreibung
Zusammenfassung:The main evidence for the hypothesis that the transitional cell in the lymphoid bone-marrow compartment is the hæmopoietic stem cell is as follows: quantitative changes in lymphoid cells in a variety of levels of erythropoietic activity point to the stem cell being within this group; the lack of any other cell in the bone-marrow capable of fitting the role on quantitative and morphological grounds; and the present finding of D.N.A. synthesis without corresponding mitosis in basophilic transitional cells.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(67)90503-X