Pemoline and Magnesium Hydroxide: Lack of Effect on RNA and Protein Synthesis

Pemoline and Magnesium Hydroxide: Lack of Effect on RNA and Protein Synthesis

Brain RNA polymerase isolated from rats treated with pemoline and magnesium hydroxide (Cylert) was not more active than enzyme from control animals. The drug did not increase enzymic activity in vitro. Pemoline did not significantly affect either RNA or protein synthesis in suspensions of Ehrlich as...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1967-07, Vol.157 (3784), p.96-97
Hauptverfasser: Stein, Herman H., Yellin, Tobias O.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Ascites
Brain - enzymology
Carcinoma, Ehrlich Tumor - metabolism
Central Nervous System Stimulants - pharmacology
Chemical suspensions
Enzyme activity
Enzymes
Hydroxides
In Vitro Techniques
Leucine - metabolism
Magnesium
Magnesium - pharmacology
Neoplasm Proteins - biosynthesis
Neurons
Nucleotidyltransferases - metabolism
Oxazoles - pharmacology
Pemoline - pharmacology
Protein synthesis
Rats
Ribonucleosides
RNA
RNA, Neoplasm - biosynthesis
Uridine - metabolism
Valine - metabolism
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Zusammenfassung:Brain RNA polymerase isolated from rats treated with pemoline and magnesium hydroxide (Cylert) was not more active than enzyme from control animals. The drug did not increase enzymic activity in vitro. Pemoline did not significantly affect either RNA or protein synthesis in suspensions of Ehrlich ascites carcinoma cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.157.3784.96