Effect of furosemide on glucose metabolism

The administration of furosemide, a benzothiadiazine analogue, to rats results in elevation of the initial and 2-hour postglucose loading blood glucose levels. Furosemide given to rats causes a decrease in the rate of glucose utilization by their adipose tissue in vitro. Furosemide added directly to...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 1967-06, Vol.16 (6), p.532-536
Hauptverfasser:	Weller, John M., Borondy, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Adipose Tissue - metabolism Animals Blood Glucose Chlorothiazide - pharmacology Furosemide - pharmacology Glucose - metabolism Glucose Tolerance Test Hydrochlorothiazide - pharmacology In Vitro Techniques Male Rats
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Zusammenfassung:	The administration of furosemide, a benzothiadiazine analogue, to rats results in elevation of the initial and 2-hour postglucose loading blood glucose levels. Furosemide given to rats causes a decrease in the rate of glucose utilization by their adipose tissue in vitro. Furosemide added directly to the incubational medium also decreases the rate of glucose utilization of normal rats' fat tissue in vitro. These effects of furosemide are similar to those produced by chlorothiazide and other benzothiadiazine compounds.
ISSN:	0026-0495 1532-8600
DOI:	10.1016/0026-0495(67)90083-2