Effect of Reserpine and Chlorpromazine on Some Cold Stress-Induced Biochemical Alterations
The effects of reserpine and chlorpromazine on cold stress-induced changes in adrenal ascorbic acid of rats and blood glucose, serum cholesterol, and serum sodium levels of rabbits were studied. While pretreatment with chlorpromazine minimized many of these stress-induced alterations, reserpine pret...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1967-02, Vol.56 (2), p.300-301 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | Dandiya, P.C. Varma, R.R. Sogani, R.K. Khuteta, K.P. |
| description | The effects of reserpine and chlorpromazine on cold stress-induced changes in adrenal ascorbic acid of rats and blood glucose, serum cholesterol, and serum sodium levels of rabbits were studied. While pretreatment with chlorpromazine minimized many of these stress-induced alterations, reserpine pretreatment aggravated them. Reserpine was found to be effective in preventing the stress-induced reduction of serum cholesterol level. Pretreatment with chlorpromazine minimized the adrenal ascorbic acid depletion due to cold stress. It also significantly prevented rise in blood sugar and fall in serum sodium produced by cold stress. |
| doi_str_mv | 10.1002/jps.2600560240 |
| format | Article |
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While pretreatment with chlorpromazine minimized many of these stress-induced alterations, reserpine pretreatment aggravated them. Reserpine was found to be effective in preventing the stress-induced reduction of serum cholesterol level. Pretreatment with chlorpromazine minimized the adrenal ascorbic acid depletion due to cold stress. It also significantly prevented rise in blood sugar and fall in serum sodium produced by cold stress.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600560240</identifier><identifier>PMID: 6026531</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Adrenal Glands - metabolism ; Animals ; Ascorbic Acid - analysis ; Blood Glucose - analysis ; Chlorpromazine - pharmacology ; Cholesterol - analysis ; Cold Temperature ; Rabbits ; Rats ; Reserpine - pharmacology ; Sodium - blood ; Stress, Physiological</subject><ispartof>Journal of pharmaceutical sciences, 1967-02, Vol.56 (2), p.300-301</ispartof><rights>1967 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1967 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4270-e90a17a70acb3e5399a1034cde969ffc5b61dbfcfa5601ff240db97f57cad01f3</citedby><cites>FETCH-LOGICAL-c4270-e90a17a70acb3e5399a1034cde969ffc5b61dbfcfa5601ff240db97f57cad01f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600560240$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600560240$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6026531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dandiya, P.C.</creatorcontrib><creatorcontrib>Varma, R.R.</creatorcontrib><creatorcontrib>Sogani, R.K.</creatorcontrib><creatorcontrib>Khuteta, K.P.</creatorcontrib><title>Effect of Reserpine and Chlorpromazine on Some Cold Stress-Induced Biochemical Alterations</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The effects of reserpine and chlorpromazine on cold stress-induced changes in adrenal ascorbic acid of rats and blood glucose, serum cholesterol, and serum sodium levels of rabbits were studied. While pretreatment with chlorpromazine minimized many of these stress-induced alterations, reserpine pretreatment aggravated them. Reserpine was found to be effective in preventing the stress-induced reduction of serum cholesterol level. Pretreatment with chlorpromazine minimized the adrenal ascorbic acid depletion due to cold stress. It also significantly prevented rise in blood sugar and fall in serum sodium produced by cold stress.</description><subject>Adrenal Glands - metabolism</subject><subject>Animals</subject><subject>Ascorbic Acid - analysis</subject><subject>Blood Glucose - analysis</subject><subject>Chlorpromazine - pharmacology</subject><subject>Cholesterol - analysis</subject><subject>Cold Temperature</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Reserpine - pharmacology</subject><subject>Sodium - blood</subject><subject>Stress, Physiological</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EKkvhyg3JJ25ZxklsN8d2VUqr1YJIq0pcLMceqy5JvNjZlvLrcZVVEQfEydLM95783hDylsGSAZQfbrdpWQoALqCs4RlZMF5CIYDJ52SRgbKoeN28JK9SugUAAZwfkIMMC16xBfl26hyaiQZHv2LCuPUjUj1aurrpQ9zGMOhfj6Mw0jYMSFeht7SdIqZUnI92Z9DSEx_MDQ7e6J4e9xNGPfkwptfkhdN9wjf795BcfTy9XH0q1p_PzlfH68LUpYQCG9BMagnadBXyqmk0g6o2FhvROGd4J5jtnHE6R2TO5ZS2a6Tj0mibB9UheT_75t_-2GGa1OCTwb7XI4ZdUkd1LTmrIYPLGTQxpBTRqW30g44PioF6LFPlMtWfMrPg3d551w1on_B9e3nfzPt73-PDf9zUxZf2L-9i1vo04c8nrY7flZCV5Op6c6Y2l2LdXpxsVJv5o5nHXOWdx6iS8Tjm_n3MB1Q2-H_F-A32-aNa</recordid><startdate>196702</startdate><enddate>196702</enddate><creator>Dandiya, P.C.</creator><creator>Varma, R.R.</creator><creator>Sogani, R.K.</creator><creator>Khuteta, K.P.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196702</creationdate><title>Effect of Reserpine and Chlorpromazine on Some Cold Stress-Induced Biochemical Alterations</title><author>Dandiya, P.C. ; Varma, R.R. ; Sogani, R.K. ; Khuteta, K.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4270-e90a17a70acb3e5399a1034cde969ffc5b61dbfcfa5601ff240db97f57cad01f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Adrenal Glands - metabolism</topic><topic>Animals</topic><topic>Ascorbic Acid - analysis</topic><topic>Blood Glucose - analysis</topic><topic>Chlorpromazine - pharmacology</topic><topic>Cholesterol - analysis</topic><topic>Cold Temperature</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Reserpine - pharmacology</topic><topic>Sodium - blood</topic><topic>Stress, Physiological</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dandiya, P.C.</creatorcontrib><creatorcontrib>Varma, R.R.</creatorcontrib><creatorcontrib>Sogani, R.K.</creatorcontrib><creatorcontrib>Khuteta, K.P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dandiya, P.C.</au><au>Varma, R.R.</au><au>Sogani, R.K.</au><au>Khuteta, K.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Reserpine and Chlorpromazine on Some Cold Stress-Induced Biochemical Alterations</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1967-02</date><risdate>1967</risdate><volume>56</volume><issue>2</issue><spage>300</spage><epage>301</epage><pages>300-301</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The effects of reserpine and chlorpromazine on cold stress-induced changes in adrenal ascorbic acid of rats and blood glucose, serum cholesterol, and serum sodium levels of rabbits were studied. While pretreatment with chlorpromazine minimized many of these stress-induced alterations, reserpine pretreatment aggravated them. Reserpine was found to be effective in preventing the stress-induced reduction of serum cholesterol level. Pretreatment with chlorpromazine minimized the adrenal ascorbic acid depletion due to cold stress. It also significantly prevented rise in blood sugar and fall in serum sodium produced by cold stress.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>6026531</pmid><doi>10.1002/jps.2600560240</doi><tpages>2</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1967-02, Vol.56 (2), p.300-301 |
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| language | eng |
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| source | Access via Wiley Online Library; MEDLINE; Alma/SFX Local Collection |
| subjects | Adrenal Glands - metabolism Animals Ascorbic Acid - analysis Blood Glucose - analysis Chlorpromazine - pharmacology Cholesterol - analysis Cold Temperature Rabbits Rats Reserpine - pharmacology Sodium - blood Stress, Physiological |
| title | Effect of Reserpine and Chlorpromazine on Some Cold Stress-Induced Biochemical Alterations |
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