Effect of Reserpine and Chlorpromazine on Some Cold Stress-Induced Biochemical Alterations

The effects of reserpine and chlorpromazine on cold stress-induced changes in adrenal ascorbic acid of rats and blood glucose, serum cholesterol, and serum sodium levels of rabbits were studied. While pretreatment with chlorpromazine minimized many of these stress-induced alterations, reserpine pretreatment aggravated them. Reserpine was found to be effective in preventing the stress-induced reduction of serum cholesterol level. Pretreatment with chlorpromazine minimized the adrenal ascorbic acid depletion due to cold stress. It also significantly prevented rise in blood sugar and fall in serum sodium produced by cold stress.