Induction of Tumors in Hamsters by Rat Rous Sarcoma RBI, Producing Chick Sarcoma Virus. I. Continuous Production of Virus Oncogenic for Chicks by Hamster Sarcoma Cells

RBI rat sarcoma cells, producing virus pathogenic for chickens, induced sarcomas in hamsters. These sarcomas were designated RBH. A double heteroinduction, i.e., chicken-rat, rat-hamster, took place. The RBH tumor was transplantable in hamsters. RBH hamster sarcoma cells and virus preparations isola...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 1970-03, Vol.44 (3), p.521-532
Hauptverfasser:	Svec, J., Svec, F., Šimkovič, D., Thurzo, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian Sarcoma Viruses Chick Embryo Chromosomes - genetics Cricetinae Karyotyping Mesocricetus Rats Sarcoma, Avian - genetics Sarcoma, Avian - pathology Sarcoma, Avian - virology Tumor Cells, Cultured
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Zusammenfassung:	RBI rat sarcoma cells, producing virus pathogenic for chickens, induced sarcomas in hamsters. These sarcomas were designated RBH. A double heteroinduction, i.e., chicken-rat, rat-hamster, took place. The RBH tumor was transplantable in hamsters. RBH hamster sarcoma cells and virus preparations isolated from them induced sarcomas in chickens. The logarithms of ID50 values were from 1.9–3.7. RBH cells adapted to growth in tissue culture, termed RBHtc, also were transplantable in hamsters. RBHtc cells continuously released a virus infectious to chickens. The chromosomal investigation of RBH and RBHtc cells indicated their hamster origin.
ISSN:	0027-8874 1460-2105 1460-2105
DOI:	10.1093/jnci/44.3.521