Conversion of Beta Sitosterol to Cholesterol Blocked in an Insect by Hypocholesterolemic Agents

Two vertebrate hypocholesterolemic agents (triparanol and 22,25-diazacholesterol) block the conversion of β-sitosterol to cholesterol in the larva of the tobacco hornworm, Manduca sexta (Johannson). A primary site of inhibitory action is the terminal step in this conversion-the reduction of desmoste...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1967-06, Vol.156 (3782), p.1637-1638
Hauptverfasser:	Svoboda, J. A., Robbins, W. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - pharmacology Biosynthesis Cholesterol - biosynthesis Cholesterols Enzymes Insect hormones Insect larvae Insecta - growth & development Insecta - metabolism Larval development Metamorphosis Phytosterols Steroids Sterols Sterols - metabolism Triparanol - pharmacology
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Beschreibung
Zusammenfassung:	Two vertebrate hypocholesterolemic agents (triparanol and 22,25-diazacholesterol) block the conversion of β-sitosterol to cholesterol in the larva of the tobacco hornworm, Manduca sexta (Johannson). A primary site of inhibitory action is the terminal step in this conversion-the reduction of desmosterol (24-dehydrocholesterol) to cholesterol. This is also the site at which these compounds inhibit de novo cholesterol biosynthesis in higher animals. Both agents severely inhibit growth and maturation of the tobacco hornworm.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.156.3782.1637