Studies on the relationship between adeno-associated virus type I (AAV-1) and adenoviruses: I. Replication of AAV-1 in certain cell cultures and its effect on helper adenovirus

Studies on the relationship between adeno-associated virus type I (AAV-1) and adenoviruses: I. Replication of AAV-1 in certain cell cultures and its effect on helper adenovirus

AAV type 1 has been shown to replicate in several species of cell cultures with the aid of certain helper adenoviruses from man, monkey, mouse, and dog. However, during the course of AAV replication the yield of the helper adenovirus was decreased. The reduction in yield of adenovirus was directly r...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Virology (New York, N.Y.) N.Y.), 1967-01, Vol.32 (1), p.52-59
Hauptverfasser: Casto, B.C., Atchison, R.W., Hammon, W.McD
Format: Artikel
Sprache:eng
Schlagworte:
Adenoviridae - metabolism
Adenoviridae - radiation effects
Adenoviruses, Canine
Culture Techniques
Cytopathogenic Effect, Viral
Helper Viruses
Microscopy, Electron
Ultraviolet Rays
Viruses - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:AAV type 1 has been shown to replicate in several species of cell cultures with the aid of certain helper adenoviruses from man, monkey, mouse, and dog. However, during the course of AAV replication the yield of the helper adenovirus was decreased. The reduction in yield of adenovirus was directly related to the quantity of AAV present and inversely- to the dose of the adenovirus challenge. The decrease in adenovirus yield was shown to be due to a reduction in the number of cells yielding virus.
ISSN:0042-6822
1096-0341
DOI:10.1016/0042-6822(67)90251-6