Hematologic Effects of Splenic Implants
1. Splenectomy in the rat results in a marked elevation in the number of circulating leukocytes and platelets. 2. Transient suppression of the leukocytosis may result from the presence of a 10 per cent splenic implant, either free in the peritoneal cavity or enclosed in a Millipore diffusion chamber...
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Veröffentlicht in: | Blood 1967-03, Vol.29 (3), p.373-384 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | 1. Splenectomy in the rat results in a marked elevation in the number of circulating leukocytes and platelets.
2. Transient suppression of the leukocytosis may result from the presence of a 10 per cent splenic implant, either free in the peritoneal cavity or enclosed in a Millipore diffusion chamber.
3. Marked and persistent suppression of postsplenectomy thrombocytosis results from the presence of a 10 per cent splenic implant, whether free or enclosed in a 0.45 µ Millipore diffusion chamber.
4. The results provide indirect evidence of a humoral substance produced by rat spleen which influences platelet levels; presumably this substance acts by suppressing thrombopoiesis. |
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ISSN: | 0006-4971 1528-0020 |
DOI: | 10.1182/blood.V29.3.373.373 |