Electrolyte-Fluid Exchanges and Renal Tissue Composition in Vasopressin Treated Polyuric-Polydipsic Rabbits.

Summary Daily administration of 2 units of vasopressin for 2 days to adult male rabbits during the polyuric-polydipsic syndrome induced by food deprivation effectively reduced the urine volume and fluid intake and increased the urinary osmolarity. There was no alteration in renal cortical or medullary electrolyte and fluid content under the conditions of these experiments. These findings establish the effectiveness of vasopressin in food-deprived polyuric-polydipsic male rabbits and suggest a possible role of an altered vasopressin release in the development of this syndrome and in the inhibitory action of estrogen.