Circadian Periodicity in Susceptibility to Lidocaine Hydrochloride

Circadian Periodicity in Susceptibility to Lidocaine Hydrochloride

Separate groups of mice standardized in an alternating 12-hour-light, 12-hour-dark regimen were treated with lidocaine hydrochloride every 3 hours over a 24-hour period. The results indicate a quantitative circadian periodicity with maximal convulsant activity at 2100 hours which was approximately a...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1967-04, Vol.156 (3771), p.100-102
Hauptverfasser: Lutsch, Edward F., Morris, Ralph W.
Format: Artikel
Sprache:eng
Schlagworte:
Albinism
Analysis of variance
Animals
Circadian Rhythm
Convulsants
Convulsions
Darkness
Dosage
Hydrochlorides
Lidocaine - pharmacology
Light
Mice
Periodicity
Scotophase
Statistical significance
Stimulants
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Zusammenfassung:Separate groups of mice standardized in an alternating 12-hour-light, 12-hour-dark regimen were treated with lidocaine hydrochloride every 3 hours over a 24-hour period. The results indicate a quantitative circadian periodicity with maximal convulsant activity at 2100 hours which was approximately a fourteen fold increase over the values observed at 1500 hours.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.156.3771.100