Inhibitory Effect of Chlorothiazide in vitro on Glucose Metabolism of Adipose Tissue

Inhibitory Effect of Chlorothiazide in vitro on Glucose Metabolism of Adipose Tissue

Summary Chlorothiazide added directly to the incubating medium decreases the in vitro rate of utilization of glucose by rats' adipose tissue. The degree of reduction in glucose utilization is greater as the amount of chlorothiazide present in the medium is increased. It can be demonstrated even...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1967-01, Vol.124 (1), p.220-223
Hauptverfasser: Weller, John M., Borondy, Maria
Format: Artikel
Sprache:eng
Schlagworte:
Adipose Tissue - drug effects
Adipose Tissue - metabolism
Animals
Chlorothiazide - pharmacology
Glucose - metabolism
In Vitro Techniques
Insulin - pharmacology
Rats
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Zusammenfassung:Summary Chlorothiazide added directly to the incubating medium decreases the in vitro rate of utilization of glucose by rats' adipose tissue. The degree of reduction in glucose utilization is greater as the amount of chlorothiazide present in the medium is increased. It can be demonstrated even with low concentrations of the drug (1 × 10−6). These experiments demonstrate a direct inhibitory effect of chlorothiazide on the glucose utilization of fat tissue.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-124-31707