Replication of the RNA genome

Several steps in the synthesis in vitro of infectious bacteriophage RNA can now be described. The reaction catalyzed by the Qβ RNA polymerase is known to involve several components, including the enzyme, host cell factors, Qβ RNA template, and the strand complementary to the Qβ RNA. The interaction...

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Veröffentlicht in:Journal of cellular physiology 1969-10, Vol.74 (S1), p.187-195
Hauptverfasser: August, J. T., Eoyang, Lillian, De Fernandez, M. T. Franze, Hasegawa, S., Kuo, C. H., Rensing, U., Shapiro, Lucille
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Sprache:eng
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Zusammenfassung:Several steps in the synthesis in vitro of infectious bacteriophage RNA can now be described. The reaction catalyzed by the Qβ RNA polymerase is known to involve several components, including the enzyme, host cell factors, Qβ RNA template, and the strand complementary to the Qβ RNA. The interaction of these components and the mechanims of the reaction appears to be considerably more complex than was proposed in earlier models.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.1040740419