Synthesis of Cyclic AMP in Dictyostelium discoideum and Polysphondylium pallidum

WE have shown that the amoebae of the cellular slime mould Dictyostelium discoideum are strongly attracted to a substance secreted by Escherichia coli and identified as cyclic AMP 1,2 . We also showed that Polysphondylium pallidum produces cyclic AMP 3 and that the amoebae of D. discoideum produce the maximum amount of the attractant at the onset of aggregation 4 . We now wish to present evidence that D. discoideum and P. pallidum synthesize cyclic AMP.