Elevation of Alkaline Phosphatase Activity in the Intestine of the Chick Embryo by Actinomycin D
DURING the development of the mouse, alkaline phosphatase activity in the duodenum rises sharply before birth, falls back slightly, and then increases twenty-fold or more between 15 and 20 days 1 . This second rise is accelerated rather than retarded by inhibitors of RNA and protein synthesis 2,3 ....
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Veröffentlicht in: | Nature (London) 1966-07, Vol.211 (5047), p.418-419 |
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Sprache: | eng |
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Zusammenfassung: | DURING the development of the mouse, alkaline phosphatase activity in the duodenum rises sharply before birth, falls back slightly, and then increases twenty-fold or more between 15 and 20 days
1
. This second rise is accelerated rather than retarded by inhibitors of RNA and protein synthesis
2,3
. Injection of actinomycin
D
, an inhibitor of DNA-dependent RNA synthesis
4
, into 9-day-old mice more than doubles their phosphatase activity within a 54 h period
3
, and the enhanced activity shows the normal increased preference for phenylphosphate over beta-glycerophosphate. Because these effects were obtained at a period of development when a considerable amount of phosphatase activity is already present, we thought it would be interesting to investigate the effect of actinomycin at a time when phosphatase activity first appears. |
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ISSN: | 0028-0836 1476-4687 |
DOI: | 10.1038/211418b0 |