The effect of dimethylsulfoxide on oxygen consumption in cold-exposed rats and hamsters

The O 2 consumption of unrestrained rats and hamsters was measured in an open circuit metabolism system during 3 hrs of exposure to an ambient temperature of 4–7°C. Both rats and hamsters which were treated with 3 or 6 g per kg of DMSO intraperitoneally consumed significantly less O 2 than saline co...

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Veröffentlicht in:Cryobiology 1966-11, Vol.3 (3), p.265-268
Hauptverfasser: Walker, T.M., Albrigo, J.L., Panuska, J.A.
Format: Artikel
Sprache:eng
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Zusammenfassung:The O 2 consumption of unrestrained rats and hamsters was measured in an open circuit metabolism system during 3 hrs of exposure to an ambient temperature of 4–7°C. Both rats and hamsters which were treated with 3 or 6 g per kg of DMSO intraperitoneally consumed significantly less O 2 than saline controls during the entire test period. The body temperatures of both rats and hamsters which received 3 g per kg of DMSO fell to below control levels but remained higher than the body temperatures of subjects receiving 6 g per kg of DMSO. O 2 consumption did not manifest this dose dependence. The results are interpreted as indicating that the depression of body temperature which follows DMSO treatment of the type described is at least partially due to an inhibition of the normal thermogenic response required for thermal homeostasis.
ISSN:0011-2240
1090-2392
DOI:10.1016/S0011-2240(66)80021-4