The Reaction of Carbamates with Cholinesterase

The Reaction of Carbamates with Cholinesterase

It has been shown that both complex formation and carbamylation are of major importance in the reaction between carbamates and cholinesterase. That carbamylation occurs has been shown by demonstration of leaving-group release as the reaction proceeds. Complex formation has been demonstrated by kinet...

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Veröffentlicht in:Molecular pharmacology 1966-11, Vol.2 (6), p.593-605
Hauptverfasser: O'Brien, R D, Hilton, B D, Gilmour, L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Carbamates
Cattle
Chemistry, Organic
Cholinesterase Inhibitors
Cholinesterases
Eels
Erythrocytes - enzymology
Kinetics
Nitrophenols
Organic Chemistry Phenomena
Tritium
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Zusammenfassung:It has been shown that both complex formation and carbamylation are of major importance in the reaction between carbamates and cholinesterase. That carbamylation occurs has been shown by demonstration of leaving-group release as the reaction proceeds. Complex formation has been demonstrated by kinetic evidence. Affinity and carbamylation constants have been measured on 11 dimethylcarbamates and 10 methylcarbamates, and correlations with alkaline hydrolyzability have been sought.
ISSN:0026-895X
1521-0111