Reaction of Formaldehyde with Unsaturated Fatty Acids during Histological Fixation

Reaction of Formaldehyde with Unsaturated Fatty Acids during Histological Fixation

FORMALDEHYDE reacts with ethylenic double bonds in the presence of an acid catalyst to give 1 : 3 glycols and 1 : 3 dioxanes (the Prins reaction) 1 . This reaction is well documented 2,3 and the following sequence is generally accepted: (a) Formation of electrophilic species: (b) Reaction with doubl...

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Veröffentlicht in:Nature (London) 1966-06, Vol.210 (5043), p.1386-1388
Hauptverfasser: JONES, DENNIS, GRESHAM, G. AUSTIN
Format: Artikel
Sprache:eng
Schlagworte:
Fatty Acids
Formaldehyde
Histological Techniques
Humanities and Social Sciences
letter
multidisciplinary
Science
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Zusammenfassung:FORMALDEHYDE reacts with ethylenic double bonds in the presence of an acid catalyst to give 1 : 3 glycols and 1 : 3 dioxanes (the Prins reaction) 1 . This reaction is well documented 2,3 and the following sequence is generally accepted: (a) Formation of electrophilic species: (b) Reaction with double bond:
ISSN:0028-0836
1476-4687
DOI:10.1038/2101386b0