Irreversible enzyme inhibitors. CLIX. Effect of substitution on transport and isozyme specificity of p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)-o-chlorophenoxyacetamido-benzenesulfonyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase

Irreversible enzyme inhibitors. CLIX. Effect of substitution on transport and isozyme specificity of p-(4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazin-1-yl)-o-chlorophenoxyacetamido-benzenesulfonyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase

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Veröffentlicht in:Journal of medicinal chemistry 1969-09, Vol.12 (5), p.894-897
Hauptverfasser: Baker, Bernard Randall, Ashton, Wallace T
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological Transport, Active - drug effects
Chemical Phenomena
Chemistry
Culture Techniques
Folic Acid Antagonists
Leukemia L1210 - enzymology
Leukemia L1210 - metabolism
Liver - enzymology
Liver - metabolism
Mice
Triazines - pharmacology
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ISSN:0022-2623
1520-4804
DOI:10.1021/jm00305a042