Polyol Pathway in Aorta: Regulation by Hormones

Aldose reductase is present in human and rabbit aortas and provides a mechanism whereby hyperglycemia can alter the metabolism of the arterial wall. Aortic sorbitol concentration is regulated by ambient glucose concentration and is increased by epinephrine, isoproterenol, dibutyryl-3′,5′-adenosine m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1969-11, Vol.166 (3908), p.1007-1008
Hauptverfasser:	Clements, Rex S., Morrison, Anthony D., Winegrad, Albert I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - metabolism Angiotensin II - pharmacology Animals Aorta Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Centromeres Cyclic AMP - pharmacology Dehydrogenases Epinephrine - pharmacology Glucuronates Hormonal regulation Hormone metabolism Humans Hyperglycemia - metabolism Isoproterenol - pharmacology Norepinephrine - pharmacology Ouabain - pharmacology Phosphates Prostaglandins Rabbits Sorbitol - metabolism Thoracic aorta Tissue samples
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Aldose reductase is present in human and rabbit aortas and provides a mechanism whereby hyperglycemia can alter the metabolism of the arterial wall. Aortic sorbitol concentration is regulated by ambient glucose concentration and is increased by epinephrine, isoproterenol, dibutyryl-3′,5′-adenosine monophosphate, ouabain, and angiotensin II.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.166.3908.1007