Structures of 5-Bromodeoxyuridine and 5-Bromouridine

Structures of 5-Bromodeoxyuridine and 5-Bromouridine

HALOGENATED deoxyuridines can be incorporated into DNA in place of the normal thymidine component, and this affects the physical properties of the DNA and has important biological consequences. For example, it makes DNA more sensitive to ultra-violet radiation 1 and it produces mutagenic changes 2 .

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Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 1966-03, Vol.209 (5029), p.1230-1232
Hauptverfasser: IBALL, J., MORGAN, C. H., WILSON, H. R.
Format: Artikel
Sprache:eng
Schlagworte:
Bromodeoxyuridine
Crystallography
Humanities and Social Sciences
letter
multidisciplinary
Science
Science (multidisciplinary)
Uridine
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Beschreibung
Zusammenfassung:HALOGENATED deoxyuridines can be incorporated into DNA in place of the normal thymidine component, and this affects the physical properties of the DNA and has important biological consequences. For example, it makes DNA more sensitive to ultra-violet radiation 1 and it produces mutagenic changes 2 .
ISSN:0028-0836
1476-4687
DOI:10.1038/2091230b0