A new method for separation and quantitative determination of metabolites of tryptamines in biological material

A new method for separation and quantitative determination of metabolites of tryptamines in biological material

A procedure for assay of 5-hydroxytryptamine and its metabolites—5-hy-droxyindole-3-acetic acid, 5-hydroxyindole-3-carboxylic acid, 5-hydroxytryptophol and 5-hydroxyindole-3-aldehyde—after separation by column chromatography, followed by spectrofluorometric determination, was elaborated. The same me...

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Veröffentlicht in:Clinica chimica acta 1969-09, Vol.25 (3), p.435-440
Hauptverfasser: Iskrić, Sonja, Stančić, Lucija, Kveder, S.
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes - analysis
Cellulose
Chromatography, Gel
Chromatography, Ion Exchange
Dextrans
Fluorometry
Hydrogen-Ion Concentration
Hydroxyindoleacetic Acid - analysis
Indoles - analysis
Methods
Serotonin - analysis
Serotonin - metabolism
Spectrophotometry
Tryptamines - analysis
Tryptamines - metabolism
Ultraviolet Rays
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Zusammenfassung:A procedure for assay of 5-hydroxytryptamine and its metabolites—5-hy-droxyindole-3-acetic acid, 5-hydroxyindole-3-carboxylic acid, 5-hydroxytryptophol and 5-hydroxyindole-3-aldehyde—after separation by column chromatography, followed by spectrofluorometric determination, was elaborated. The same method has proved to be applicable also to tryptamine and its metabolites, as well as to 5-methoxytryptamine and its metabolites.
ISSN:0009-8981
1873-3492
DOI:10.1016/0009-8981(69)90205-8