Relationships of V1030, V1880 and Pett Viruses to the Prototype A24 Coxsackievirus.

Summary Two viruses isolated from children vaccinated with inactivated polio-diphtheria-pertussis-tetanus vaccine and designated VI030 and VI880 were submitted to this laboratory as possible new enterovirus prototypes. Cross serum neutralization, complement fixation and hemagglutination inhibition tests indicated that V1030 and V1880 viruses are antigenically related to the prototype coxsackievirus A24. However, both viruses, when tested after several passages in human amnion cells, failed to show mouse pathogenicity. These two viruses appear to be prime strains of coxsackievirus A type 24 that are either devoid of mouse pathogenicity or have lost this property due to excessive passage in cell culture. No antigenic relationship between Pett virus and coxsackievirus A24 could be detected.