Acetylcholine in the treatment of idiopathic respiratory distress syndrome

Five infants critically ill with IRDS were treated with acetylcholine. Three of them died. The Pa CO 2 and pH were not favorably affected by the drug in any of the 5 infants and the Pa O 2 either remained unchanged or fell. These observations suggest that the course of fully developed IRDS is not al...

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Veröffentlicht in:	The Journal of pediatrics 1966-11, Vol.69 (5), p.817-825
Hauptverfasser:	Moss, Arthur J., Emmanouilides, George C., Rettori, Ovidio, Adams, Forrest H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - therapeutic use Blood Gas Analysis Blood Pressure - drug effects Blood Pressure Determination Female Heart Rate - drug effects Humans Hydrogen-Ion Concentration Infant, Newborn Male Pulmonary Circulation - drug effects Respiration - drug effects Respiratory Distress Syndrome, Newborn - drug therapy
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Zusammenfassung:	Five infants critically ill with IRDS were treated with acetylcholine. Three of them died. The Pa CO 2 and pH were not favorably affected by the drug in any of the 5 infants and the Pa O 2 either remained unchanged or fell. These observations suggest that the course of fully developed IRDS is not altered by acetylcholine, and use of this drug in these circumstances may even be harmful.
ISSN:	0022-3476 1097-6833
DOI:	10.1016/S0022-3476(66)80134-8